The Nightmare Before ChristmasTim Burton's The Nightmare Before Christmas (1993) is a stop-action animated musical film about the inhabitants of Halloween Town who take over Christmas one year, directed by stop-motion animator Henry Selick. The film is loosely based on drawings and a poem by Tim Burton, and he served as co-producer. He did not direct the film as is sometimes believed, but he was still heavily involved. The film was released by Touchstone Pictures, a film studio owned by the Walt Disney Company, after the main Walt Disney Pictures division balked at some of the darker content. SynopsisSpoiler warning: Plot and/or ending details follow.The film centers around Jack Skellington, the much adored leader of Halloween Town. Although Jack is loved and respected by the townspeople, he feels that there is something unknown to him that is missing from his life. One day while wandering in the woods with his dog zero, Jack discovers a circle of trees unlike anything that he has seen before. Each tree has a door on it representing a different holiday. When Jack opens the Christmas door he is sucked into the wonderful world of Christmas Town. Jack is mesmerized by the color and cheerfulness of the holiday, and realizes that this is exactly what he has been searching for. When Jack returns to Halloween Town he locks himself in his home and performs countless experiments to try and better understand Christmas Town. Soon Jack calls a meeting in Town Hall and reveals his plans to takeover Christmas. All of the townspeople pitch in to create their own twisted version of the holiday. Sally, a close friend and admirer of Jack, tries to warn him that she thinks it is a bad idea to take over something he knows nothing about, but Jack is too wrapped in his fantasies to listen. In order to successfully take over Christmas, Jack enlists the help of a trio of misfits named Lock, Shock, and Barrel to kidnap Santa Claus. The children take him to a villainous monster named Oogie Boogie. On Christmas Eve, Jack embarks on his makeshift sleigh flanked by skeleton reindeers and his ghost dog, Zero. Jack's scary and sometimes dangerous presents put the people in the real world in a panic and they begin to call the police with reports of attacking Christmas toys and an imposter Santa Claus. In not too long, Jack is targeted by the military and shot down. At the same time, Sally goes to try and rescue Santa Claus but is captured by Oogie Boogie and the two are in risk of their lives. When Jack finds himself and his sleigh crashed in a graveyard and his vision of Christmas wrecked, he realizes that he is the Pumpkin King and that he should stick to what he knows best, namely Halloween. In order to salvage Christmas Jack hurries back to Halloween Town and confronts Oogie Boogie. After Jack destroys Oogie, revealing him to be nothing more that a burlap monster full of bugs, Santa Claus hurries to deliver the correct presents and save Christmas. Once Santa has delivered all the presents he brings the Christmas spirit to Halloween Town, including snow, and the citizens are amazed by the new sensations. Finally, Sally reveals her true feelings to Jack and in the end of the movie the two begin a relationship. LegacyWhen the movie originally was released it failed to live up to expectations and was considered a flop. However, when it was released on video a new audience began to discover it and slowly it began to grow a cult following. The same studio that produced Nightmare later created another stop motion movie based on the Roald Dahl book, James and the Giant Peach (1996), though it did not receive the same amount of success. In 2005, Tim Burton returned to the media of stop motion with his new film, Corpse Bride. MerchandisingCurrently, 'Nightmare Before Christmas' has become one of the most sucessful franchises in terms of selling merchandise, and the film has developed a group of very dedicated collectors. Much of the original merchandise has become highly collectible and rare. In the past few years many retail stores like Hot Topic have obtained the rights to sell products and have flooded the market with what some believe to be cheap and uninspired merchandise. Technical data
Starfield Creations Cast (voices)
On the soundtrack album, Patrick Stewart voices the opening narrative poem. A second poem, also read by Stewart, is included before the "End Credits" music; in this passage, Santa Claus describes a visit he made to Halloween Town many years after the events of the film. Haunted Mansion HolidayFor the past five years, the Disneyland and Tokyo Disneyland in California and Japan have received a Nightmare Before Christmas themed overlay, called Haunted Mansion Holiday, for their Haunted Mansion attractions. The attractions are closed in October each year for themes to be completely overhauled, and open until January of the next year. The attraction generally has a one night opening event each year that includes special guests, a dinner, special merchandise, and a ride through the attraction, although the Happiest Celebration on Earth halted that in Disneyland in 2005. Starting in 2001, the ride has included a score that was written specifically for the ride by film composer Danny Elfman. There has been a great deal of speculation recently that 2006 will be last year for the event, allegedly at Tim Burton's request. Video gamesA video game based on the original movie was released in 2005. The Nightmare Before Christmas: Oogie's Revenge is an action/adventure game developed by Capcom from Japan for the PlayStation 2 and Xbox systems. Intended to be a sequel to the movie, the game features the return of all the well-known characters in a new and arguably darker story with upgraded versions of the movie's songs. In the story, Jack leaves Halloween Town to satisfy his curiosity, but during his absence, Oogie Boogie is reconstructed and by the time Jack returns he has taken over Halloween Town and tricked its people into thinking Jack has abandoned them. Now Jack has to stop Oogie Boogie's evil plans as he attempts to take over the other holiday worlds, and the 'real' world. The game features controls similar to Devil May Cry. The game features a weapon known as a 'Soul Robber'. In the game you get other costumes such as "Pumpkin King," and "Santa Jack".
Halloween Town also appears as one of the worlds in the Square Enix/Disney Kingdom Hearts video game series (in fact, it was the movie's first official video game appearance). In this game, Jack tries to create an artificial heart so he can control the Heartless for use in his "Heartless Halloween," but the plan goes awry when Oogie Boogie (who was one of the Disney villains allied with Maleficent) steals the heart, ingests it, and tries to use it to control the Heartless for his own purposes. Jack then teams up with Sora and the others to stop Oogie Boogie's plans. Jack can also join Sora's party whenever they are in Halloween Town. Kingdom Hearts II follows the movie plot, where Jack tries to take over Santa Claus' place on Christmas. Trading Card GameSometime during 2005, a card game, titled The Nightmare Before Christmas TCG, was released. Released were starter decks and a base set. In March 2006, there will be a new set, called Christmas Town, and a Tournament Kit released. This page about jack skellington includes information from a Wikipedia article. Additional articles about jack skellington News stories about jack skellington External links for jack skellington Videos for jack skellington Wikis about jack skellington Discussion Groups about jack skellington Blogs about jack skellington Images of jack skellington |
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In March 2006, there will be a new set, called Christmas Town, and a Tournament Kit released. Instead, the agency relies on other methods, including death certificates and urging physicians to send suspicious cases to the National Prion Disease Pathology Surveillance Center (NPDPSC) at Case Western Reserve University in Cleveland, which is funded by the CDC. Released were starter decks and a base set. In the U.S., the CDC has refused to impose a national requirement that physicians and hospitals report cases of the disease. Sometime during 2005, a card game, titled The Nightmare Before Christmas TCG, was released. In the UK anyone with possible vCJD symptoms must be reported to the UK Creutzfeldt-Jakob Disease Surveillance Unit and so it is unlikely that any cases would be missed. Kingdom Hearts II follows the movie plot, where Jack tries to take over Santa Claus' place on Christmas. As for vCJD in humans, autopsy tests are not always done and so those figures too are likely to be too low, but probably by a lesser fraction. Jack can also join Sora's party whenever they are in Halloween Town. It is noticeable that there are no cases reported in Australia and New Zealand where cattle are mainly fed outside on grass pasture and, mainly in Australia, non-grass feeding is done only as a final finishing process before the animals are processed for meat. Jack then teams up with Sora and the others to stop Oogie Boogie's plans. Even so, currently the only reliable test is examination of tissues during an autopsy. In this game, Jack tries to create an artificial heart so he can control the Heartless for use in his "Heartless Halloween," but the plan goes awry when Oogie Boogie (who was one of the Disney villains allied with Maleficent) steals the heart, ingests it, and tries to use it to control the Heartless for his own purposes. Newer tests are faster, more sensitive, and cheaper, so it is possible that future figures may be more comprehensive. Halloween Town also appears as one of the worlds in the Square Enix/Disney Kingdom Hearts video game series (in fact, it was the movie's first official video game appearance). Tests are also difficult as the altered prion protein has very small levels in blood or urine, and no other signal has been found. Finklestein, and others--to both stop Oogie and save Halloween. At the opposite end of the scale, Japan tests all cattle at the time of slaughter. With these creepy wheels set in motion, it will be up to Jack and his friends--including characters such as Zero, Sally, Dr. For instance, in the EU the cattle tested are older (30 months+), while many cattle are slaughtered earlier than that. Jack soon discovers that these nasty insects are under the control of Oogie Boogie, who's looking to take over Halloween himself. The tests used for detecting BSE vary considerably as do the regulations in various jurisdictions for when, and which cattle, must be tested. The game's plot will kick off with the invasion of some unusual bugs in Halloween Town. The figures given above for BSE are certainly too low, and most likely by a considerable amount. The side-scrolling adventure game centers around the first time Jack faced off against his nemesis, Oogie Boogie, to eventually become the Pumpkin King. BSE is the disease in cattle, whilst vCJD is the disease in people. The Pumpkin King is a side-scrolling action platformer in which you'll control Jack Skellington and use a number of different weapons to fight enemies and traverse obstacles. The following table summarizes reported cases of BSE and of vCJD by country. The opposite of the Playstation and Xbox versions, the GBA game works as a prequel to the movie. Indeed, US meat producer Creekstone Farms alleges that the USDA is preventing BSE testing from being conducted [10]. In the game you get other costumes such as "Pumpkin King," and "Santa Jack". [9] Compliance with the regulations was shown to be extremely poor before the discovery of the Washington cow, but industry representatives report that compliance is now 100%. The game features a weapon known as a 'Soul Robber'. In February 2001, the USGAO reported that the FDA, which is responsible for regulating feed, had not adequately policed the various bans. The game features controls similar to Devil May Cry. [8] A proposal to end the use of cow blood, restaurant scraps, and chicken litter (fecal matter, feathers) in January 2004 was eventually scrapped, despite the efforts of some advocates of such a policy, who cite the fact that cows are herbivores, and that blood and fecal matter could potentially carry BSE. Now Jack has to stop Oogie Boogie's evil plans as he attempts to take over the other holiday worlds, and the 'real' world. In addition, it is legal for ruminants to be fed byproducts from some of these animals. In the story, Jack leaves Halloween Town to satisfy his curiosity, but during his absence, Oogie Boogie is reconstructed and by the time Jack returns he has taken over Halloween Town and tricked its people into thinking Jack has abandoned them. However, the byproducts of ruminants can still be legally fed to pets or other livestock and poultry such as pigs and chickens. Intended to be a sequel to the movie, the game features the return of all the well-known characters in a new and arguably darker story with upgraded versions of the movie's songs. In 1997, regulations prohibited the feeding of mammalian byproducts to ruminants such as cows and goats. The Nightmare Before Christmas: Oogie's Revenge is an action/adventure game developed by Capcom from Japan for the PlayStation 2 and Xbox systems. regulations only partially prohibit the use of animal byproducts in feed. A video game based on the original movie was released in 2005. However, U.S. There has been a great deal of speculation recently that 2006 will be last year for the event, allegedly at Tim Burton's request. As a result, the use of animal byproduct feeds was never common, as it was in Europe. Starting in 2001, the ride has included a score that was written specifically for the ride by film composer Danny Elfman. Soybean meal is cheap and plentiful in the United States. The attraction generally has a one night opening event each year that includes special guests, a dinner, special merchandise, and a ride through the attraction, although the Happiest Celebration on Earth halted that in Disneyland in 2005. [7]. The attractions are closed in October each year for themes to be completely overhauled, and open until January of the next year. Trace-backs revealed that this cow originated from a herd in Texas, making it the first BSE cow native to the United States. For the past five years, the Disneyland and Tokyo Disneyland in California and Japan have received a Nightmare Before Christmas themed overlay, called Haunted Mansion Holiday, for their Haunted Mansion attractions. Tests carried out at the USDA laboratory in Ames, Iowa indicated the presence of BSE, and after subsequent confirmation from the Weybridge Veterinary Laboratory in the United Kingdom, the USDA acknowledged the second case of BSE on June 24. A second poem, also read by Stewart, is included before the "End Credits" music; in this passage, Santa Claus describes a visit he made to Halloween Town many years after the events of the film. On June 10, 2005, the USDA reported a possible case of BSE in the United States. On the soundtrack album, Patrick Stewart voices the opening narrative poem. No case of variant Creutzfeldt-Jakob disease has occurred in North America so far, except among those who have traveled to Europe. Starfield Creations. [6]. In the past few years many retail stores like Hot Topic have obtained the rights to sell products and have flooded the market with what some believe to be cheap and uninspired merchandise. Japanese inspectors found material from cattle backbone in three of 41 boxes in a 858-pound shipment of beef from Atlantic Veal & Lamb. Much of the original merchandise has become highly collectible and rare. Brooklyn-based Atlantic Veal & Lamb inspectors failed to notice there was bone material included in a shipment of veal to Japan. Currently, 'Nightmare Before Christmas' has become one of the most sucessful franchises in terms of selling merchandise, and the film has developed a group of very dedicated collectors. [5] It was, however, quick to reinstate the ban. In 2005, Tim Burton returned to the media of stop motion with his new film, Corpse Bride. Japan lifted its ban on US beef in December 2005. The same studio that produced Nightmare later created another stop motion movie based on the Roald Dahl book, James and the Giant Peach (1996), though it did not receive the same amount of success. [4]. However, when it was released on video a new audience began to discover it and slowly it began to grow a cult following. Notwithstanding, Japanese beef exports, chiefly the expensive wagyu, have been banned in the United States since Japan experienced its first case of BSE in January 2001. When the movie originally was released it failed to live up to expectations and was considered a flop. Since Japan and South Korea are the first- and third-largest importers of US beef, respectively, the economic impact of their bans is significant both for American cattle ranchers and for Japanese and Korean beef consumers. Finally, Sally reveals her true feelings to Jack and in the end of the movie the two begin a relationship. beef until the authorities can be assured of its safety. Once Santa has delivered all the presents he brings the Christmas spirit to Halloween Town, including snow, and the citizens are amazed by the new sensations. discovery of BSE in 2003, Japan and South Korea instituted temporary bans on the import of U.S. After Jack destroys Oogie, revealing him to be nothing more that a burlap monster full of bugs, Santa Claus hurries to deliver the correct presents and save Christmas. Shortly after the U.S. In order to salvage Christmas Jack hurries back to Halloween Town and confronts Oogie Boogie. surveillance relied on a test that gave results only after two weeks, after which time the meat from an animal usually has all been sold. When Jack finds himself and his sleigh crashed in a graveyard and his vision of Christmas wrecked, he realizes that he is the Pumpkin King and that he should stick to what he knows best, namely Halloween. Until the switch, U.S. At the same time, Sally goes to try and rescue Santa Claus but is captured by Oogie Boogie and the two are in risk of their lives. authorities called for a switch to the testing procedure that is used in the United Kingdom, which yields its results in one day. In not too long, Jack is targeted by the military and shot down. U.S. Jack's scary and sometimes dangerous presents put the people in the real world in a panic and they begin to call the police with reports of attacking Christmas toys and an imposter Santa Claus. The meat of the BSE-positive cow went to market, but some of it was successfully recalled before it was sold to consumers. On Christmas Eve, Jack embarks on his makeshift sleigh flanked by skeleton reindeers and his ghost dog, Zero. Only 200,000 cows slaughtered in 2003 were downers. The children take him to a villainous monster named Oogie Boogie. [3] Therefore it is not clear how effective the ban is in reducing the number of infected cattle consumed. In order to successfully take over Christmas, Jack enlists the help of a trio of misfits named Lock, Shock, and Barrel to kidnap Santa Claus. Furthermore, there is some dispute as to whether the cow was a downer or not. Sally, a close friend and admirer of Jack, tries to warn him that she thinks it is a bad idea to take over something he knows nothing about, but Jack is too wrapped in his fantasies to listen. While the Washington cow that tested positive for BSE was reportedly unable to stand, veterinarians say the condition was unrelated to BSE. All of the townspeople pitch in to create their own twisted version of the holiday. The government plans to double the number of cattle tested in 2004, and has banned the use of "downer cows" for human consumption. Soon Jack calls a meeting in Town Hall and reveals his plans to takeover Christmas. authorities have very little idea of how many American beef cattle might have the disease. When Jack returns to Halloween Town he locks himself in his home and performs countless experiments to try and better understand Christmas Town. As a result, U.S. Jack is mesmerized by the color and cheerfulness of the holiday, and realizes that this is exactly what he has been searching for. Therefore, it is possible that even among those cattle that are tested and classified as negative, a proportion nevertheless may be contagious. When Jack opens the Christmas door he is sucked into the wonderful world of Christmas Town. Current tests reveal the presence of misshaped prions when they are abundant, but it is not known how far the disease must progress in an individual to transmit it to others. Each tree has a door on it representing a different holiday. [2] Agriculture Secretary Ann Veneman called the discovery "a clear indication that our surveillance and detection program is working." However, the United States tested only 20,526 cows in 2003 out of the roughly 35 million slaughtered. One day while wandering in the woods with his dog zero, Jack discovers a circle of trees unlike anything that he has seen before. On December 23, 2003, the first case of BSE in the United States was found in a single Holstein cow in Mabton, Washington, although trace-backs later revealed that this cow originated from a Canadian herd. Although Jack is loved and respected by the townspeople, he feels that there is something unknown to him that is missing from his life. The United States also issued a temporary ban on all Canadian beef. The film centers around Jack Skellington, the much adored leader of Halloween Town. The animal was destroyed after being declared unfit for consumption. . It occurred in a single older cow that may have contracted the disease from contaminated feed in earlier years. The film was released by Touchstone Pictures, a film studio owned by the Walt Disney Company, after the main Walt Disney Pictures division balked at some of the darker content. The second was reported in Canada on May 20, 2003. He did not direct the film as is sometimes believed, but he was still heavily involved. The first was in 1993, involving an animal born in Britain. The film is loosely based on drawings and a poem by Tim Burton, and he served as co-producer. As of January 2005, five BSE-infected cattle have been identified in North America. Tim Burton's The Nightmare Before Christmas (1993) is a stop-action animated musical film about the inhabitants of Halloween Town who take over Christmas one year, directed by stop-motion animator Henry Selick. regarding a possible risk of transmission of the BSE agent in gelatin products.". Ken Page: Oogie Boogie. that there were some licensed surgical sutures derived from French bovine material." Concerns were also raised: ".. Paul Reubens: Lock. expressed concerns about the possible transmission of the BSE/scrapie agent to man through use of certain cosmetic treatments." Sources in France reported to the British Medicines Control Agency: ".. Glenn Shadix: Mayor. there was no insulin sourced from cattle in the UK or Ireland and that the situation in other countries was being monitored." In 1991 a European Community Commission: ".. Finklestein. no licensing action is required at present in regard to products produced from bovine material or using prepared bovine brain in nutrient media and sourced from outside the United Kingdom, the Channel Isles and the Republic of Ireland provided that the country of origin is known to be free of BSE, has competent veterinary advisers and is known to practise good animal husbandry." In 1990 the British Diabetic Association became concerned regarding the safety of bovine insulin and the government licensing agency assured them that: ".. William Hickey: Dr. use of bovine insulin in a small group of mainly elderly patients was noted and it was recognised that alternative products for this group were not considered satisfactory." A medicines licensing committee report that same year recommended that: ".. Catherine O'Hara: Sally, Shock. identify relevant manufacturers and obtain information about the bovine material contained in children’s vaccines, the stocks of these vaccines and how long it would take to switch to other products." It was further reported that the: ".. Danny Elfman: Jack Skellington (singing), Barrel, The Clown with the tearawayface. ".. Chris Sarandon: Jack Skellington (speaking). On May 7, 1999 in his written statement number 476 to the BSE Inquiry, David Osborne Hagger reported on behalf of the Medicines Control Agency that in a previous enquiry the Agency had been asked to:. MPAA rating: PG. During the course of the investigation into the BSE epidemic, an enquiry was also made into the activities of the Department of Health and its Medicines Control Agency. Runtime: 76 minutes. [1]. Genre: animation, fantasy, satire, musical. In 2005 a controversial paper in The Lancet suggested that BSE might have originated in British cattle when they ate imported animal feed that included infected human remains from Hindu funeral ceremonies in India. Specifications: Technicolor, 35 mm 1.66:1 (colours, Dolby digital sound). So far nothing is known about the relative transmissibility of the two disease strains of BSE prion. American picture. But cruder measures yield a "biochemical signature" by which the newly discovered cattle strain appears different from the familiar one, but similar to the clumped prions in humans with traditional CJD (Creutzfeldt-Jakob Disease).The finding of a second strain of BSE prion raises the possibility that transmission of BSE to humans has been underestimated, because some of the individuals diagnosed with spontaneous or "sporadic" CJD may have actually contracted the disease from tainted beef. Released on: October 13, 1993. Very little is known about the shape of disease-causing prions, because their insolubility and tendency to clump thwarts application of the detailed measurement techniques of structural biology. Music by: Danny Elfman. In other words, this implies a second strain of BSE prion. Written by: Caroline Thompson and Michael McDowell. In 2004 researchers reported evidence of a second contorted shape of prions in a rare minority of diseased cattle. Directed by: Henry Selick. As a result the full extent of the human vCJD outbreak is still not fully known. Title: The Nightmare Before Christmas. This is attributed to the long incubation period for prion diseases, which are typically measured in years or decades. Although the BSE epidemic was eventually brought under control by culling all suspect cattle populations, people are still being diagnosed with vCJD each year (though the number of new cases currently seems to be dropping). It is estimated that 400,000 cattle infected with BSE entered the human food chain in the 1980s. Disease incidence also appears to correlate with slaughtering practices that led to the mixture of nervous system tissue with hamburger and other beef. For many of the vCJD patients, direct evidence exists that they had consumed tainted beef, and this is assumed to be the mechanism by which all affected individuals contracted it. Up to date statistics on all types of CJD are published by the UK CJD Surveillance Centre in Edinburgh. There is also some concern about those who work with (and therefore inhale) cattle meat and bone meal, such as horticulturists, who use it as fertilizer. Three cases of vCJD occurred in people who had lived in or visited Britain--one each in Ireland, Canada and the United States. Of the 157 cases of vCJD in humans so far, 148 occurred in the United Kingdom, 6 in France, and one in Italy. This is a separate disease from 'classical' Creutzfeldt-Jakob disease, which is not related to BSE and has been known about since the early 1900s. Following an epidemic of BSE in Britain, 157 people (as of 2004) acquired and died of a disease with similar neurological symptoms subsequently called vCJD, or (new) variant Creutzfeldt-Jakob disease. While other European countries like Germany required said animal byproducts to undergo a high temperature steam boiling process, this requirement had been eased in Britain as a measure to keep prices competitive. A contributing factor seems to have been a change in British laws that allowed a lower temperature sterilization of the protein meal. A change to the rendering process in the early 1980s may have resulted in a large increase of the infectious agents in the cattle feed. However, soybeans do not grow well in Europe, so cattle raisers throughout Europe turned to the less expensive animal byproduct feeds as an alternative. Worldwide, Soybean meal is the primary plant-based protein supplement fed to cattle. The use of meat and bone meal as a protein supplement in cattle feed was widespread in Europe prior to about 1987. The tissues that contain most of the pathogenic molecules are those of the brain and the nervous system, although infectious amounts have been shown experimentally to be present elsewhere, such as in blood. As more animals became ill, more infectious tissue got into the feed, and so the number of cases reached epidemic proportions. This practice allowed the accumulation of prions over many generations. Prior to the BSE epidemic, cattle were fed with meat and bone meal, a high-protein substance obtained from the remnants of butchered animals, including cows and sheep. However, sheep and cattle TSEs are quite different and it is now thought more likely that BSE could have originated with a case of sporadic BSE in a single bovine. It was first believed to have originated in sheep, in which the related prion disease scrapie is common (such diseases collectively are called "transmissible spongiform encephalopathies" or TSEs). The British BSE epidemic in cattle was recognised in 1986. These aggregate to form dense plaque fibers, which lead to the microscopic appearance of "holes" in the brain, degeneration of physical and mental abilities and ultimately death. In the brain these proteins cause native cellular prion protein to deform into the infectious state which then goes on to deform further prion protein in an exponential cascade. Transmission can occur when healthy animals consume tainted tissues from others with the disease. Most TSEs, however, occur sporadically in animals that do not have a prion protein mutation. TSEs can arise in animals that carry a rare mutant prion allele, which expresses prions that contort by themselves into the disease-causing shape. BSE is a type of transmissible spongiform encephalopathy (TSE). Misshapen ("misfolded") prion proteins carry the disease between individuals and cause deterioration of the brain. Unlike other kinds of infectious disease which are spread by microbes, the infectious agent in BSE is a specific type of protein. . While never having killed cattle on a scale comparable to other dreaded livestock diseases, such as foot and mouth and rinderpest, BSE has attracted wide attention because people assume humans can contract the disease, but it has never been proven that BSE has any link to variant Creutzfeld-Jakob disease (vCJD), sometimes called new variant Creutzfeld-Jakob disease (nvCJD), a human brain-wasting disease. The disease appears transmissible to humans. Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is a fatal, neurodegenerative disease of cattle, which infects by a mechanism that shocked biologists on its discovery in late 20th century. |