Twin

Fraternal twin boys in the tub

The term twin most notably refers to two individuals (or one of two individuals) who have shared the same uterus (womb) and are usually, but not necessarily, born on the same day. A fetus alone in the womb is called a singleton. Due to the limited size of the mother's womb, multiple pregnancy is much less likely to carry to full term than singleton birth (twins usually around 34 to 36 weeks). Since some premature births often have health consequence to the babies, twins birth are often handled with special procedures.

Types of twins

Fraternal twins

Fraternal twins (commonly known as "non-identical twins") usually occur when two fertilized eggs are implanted in the uterine wall at the same time. The two eggs form two zygotes, and these twins are therefore also known as dizygotic as well as "biovular" twins.

Dizygotic twins, like any siblings, have a very small chance of having the exact same chromosome profile, but most likely have a number of different chromosomes that distinguish them. Dizygotic twins may be a different sex or the same sex, just as with any other siblings.

Studies show that there is a genetic basis for fraternal twinning—that is, non-identical twins do run in families. However, it is only the female that has any influence on the chances of having fraternal twins as the male cannot make her release more than one ovum.

Identical twins

Identical twins occur when a single egg is fertilized to form one zygote (monozygotic) but the zygote then divides into two separate embryos. The two embryos develop into fetuses sharing the same womb. Depending on the stage at which the zygote divides, identical twins may share the same amnion (in which case they are known as monoamniotic) or not (diamniotic). Diamniotic identical twins may share the same placenta (known as monochorionic) or not (dichorionic). All monoamniotic twins are monochorionic. Also note that any monochorionic or monoamniotic twins are identical twins. This condition does not occur for fraternal twins.

The later in pregnancy that twinning occurs, the more structures will be shared. Zygotes that twin at the earliest stages will be diamniotic and dichorionic ("di-di"). Twinning between 4 to 8 days after fertilization typically results in monochorionic-diamniotic ("mono-di") twins. Twinning between 8 to 12 days after fertilization will usually result in monochorionic-monoamniotic ("mono-mono") twins. Twinning after 12 days post-fertilization will typically result in conjoined twins.

Sharing the same amnion (or the same amnion and placenta) can cause complications in pregnancy. For example, the umbilical cords of monoamniotic twins can become entangled, reducing or interrupting the blood supply to the developing fetus. Monochorionic twins, sharing one placenta, usually also share the placental blood supply. These twins may develop such that blood passes disproportionately from one twin to the other through connecting blood vessels within their shared placenta, leading to twin-to-twin transfusion syndrome. About 50% of mono-mono twins die from umbilical cord entanglement.

Monozygotic twins are genetically identical unless there has been a mutation in development, and they are almost always the same gender. (On extremely rare occasions, an original XXY zygote may form monozygotic boy/girl twins by dropping the Y chromosome for one twin and the extra X chromosome for the other.) Monozygotic twins generally look alike, although sometimes they appear as mirror images of each other. Examination of details such as fingerprints can tell them apart. As they mature, identical twins often become less alike because of lifestyle choices or external influences such as scars.

While it was originally thought that identical twins do not run in families, but occur more or less randomly, some recent research has suggested that a genetic predisposition may exist. The exact cause for the splitting of a zygote or embryo is unknown.

Identical twins can behave as differently as any other siblings (a matter of much interest to psychologists). They develop their own individual personalities to enable themselves to be identified as individual persons. Many identical twins spend most of their time together (especially as children), so people often assume that they will behave alike just as they look alike; however, this is not the case. Twins are unique individuals that establish their own individual likes and dislikes. There are usually obvious signs of differences when the identical twins are observed separately or together.

Identical twins have identical DNA but differing environmental influences throughout their lives affect which genes are switched on or off. This is called epigenetic modification. A study of 80 pairs of twins ranging in age from 3 to 74 showed that the youngest twins have relatively few epigenetic differences. The number of differences between identical twins increases with age. 50-year-old twins had over 3 times the epigenetic difference that the 3-year-old twins had. Twins who had spent their lives apart (such as those adopted by two different sets of parents at birth) had the greatest difference. (Fraga, et al., 2005).

Some percentage of monozygotic twins are called "mirror twins" or mirror image twins. These are identical twins with opposite features, that is one may be right handed and the other may be left handed; hair will whorl in the opposite direction, and so on. The incidence of mirror twinning is comparatively rare. They result from a late split of the fertilized egg at around 9-12 days. One mirror may or may not have situs inversus. This is where some or all of the organs will be on the opposite side of the body, such as the heart being on the right(Dextrocardia). Such conditions are usually associated with a higher incidence of other birth defects.

Complications of twin pregnancy

Vanishing twins

Researchers suspect that more pregnancies start out as multiples than come to term that way. Early obstetric ultrasonography exams sometimes reveal an "extra" fetus, which fails to develop and instead disintegrates and vanishes.

Conjoined twins

Conjoined twins are monozygotic twins, whose bodies are joined together at birth. This occurs where the single zygote of identical twins fails to separate completely. This condition occurs in about 1 in 100,000 pregnancies.

Parasitic twins

Sometimes one twin fetus will fail to develop completely and continue to cause problems for its surviving twin. One fetus acts as a parasite towards the other.

Sometimes the parasitic twin just becomes an almost indistinguishable part of the other.

A chimera is a person who is a completely normal human with no extra parts, but some of the parts actually came from his or her twin. A chimera may arise either from identical twin fetuses (where it would be impossible to detect), or from dizygotic fetuses, which could be identified by chromosomal comparisons from various parts of the body.

Miscarried twin

Occasionally, a woman will suffer a miscarriage early in pregnancy, yet the pregnancy will continue; one twin was miscarried but the other was able to be carried to term. Similar to vanishing twin.

Human twins

Historically, about 1 in 80 human births (1.2%) has been the result of a twin pregnancy. The rate of twinning varies greatly among ethnic groups, ranging as high as about 6% for the Yoruba or 10% for a tiny Brazilian village (see [1]). The widespread use of fertility drugs causing hyperovulation (stimulated release of multiple eggs by the mother) has caused what some call an "epidemic of multiple births". In 2001, for the first time ever in the US, the twinning rate exceeded 3% of all births. Thus, approximately 6% of children born in the US in 2001 were twins.

Nevertheless, the rate of identical twins remains at about 1 in 250 across the globe, further suggesting that pregnancies resulting in identical twins occur randomly.

Multiple births

Sometimes multiple births may involve more than two fetuses. If there are three, they are called triplets; four, quadruplets; five, quintuplets; six, sextuplets, seven, septuplets, and so on. Before the advent of ovulation-stimulating drugs, triplets were quite rare (approximately 1 in 8000 births) and higher order births so rare as to be almost unheard of. Multiple pregnancies are usually delivered before the full term of 40 weeks gestation: the average length of pregnancy is around 36 weeks for twins, 34 weeks for triplets and 32 weeks for quadruplets.

Predisposing factors

The cause of monozygotic twinning is unknown. Fewer than 20 families have been described with an inherited tendency towards monozygotic twinning (people in these families have nearly a 50% chance of delivering monozygotic twins). Some evidence suggests that the environment of the womb causes the zygote to split in most cases.

Dizygotic twin pregnancies are slightly more likely when the following factors are present in the woman:

  • She is of African descent
  • Between the age of 30 and 40 years
  • Greater than average height and weight
  • Several previous pregnancies.

Women undergoing certain fertility treatments may have a greater chance of multiple births. This can vary depending on what types of fertility treatments are used. With in vitro fertilisation (IVF), this is primarily due to the insertion of multiple embryos into the uterus. Some other treatments such as the drug Clomid can stimulate a woman to release multiple eggs, allowing the possibility of multiples. Many fertility treatments have no effect on the likelihood of multiple births.

Twin studies

Twin studies are studies that assess identical (monozygotic) twins for medical, genetic, or psychological characteristics to try to isolate genetic influence from environmental influence. Twins that have been separated early in life and raised in separate households are especially sought-after for these studies, which have been invaluable in the exploration of human nature.

Unusual Twinnings

There are some patterns of twinning that are exceedingly rare: while they have been reported to happen, they are so unusual that most obstetricians or midwives may go their entire careers without encountering a single case.

Among fraternal twins, in rare cases, the eggs are fertilised at different times with two or more acts of sexual intercourse, either within one menstrual cycle (superfecundation) or, even more rarely, later on in the pregnancy (superfetation). This can lead to the possibility of a woman carrying fraternal twins with different fathers (that is, half-siblings). One 1992 study estimates that the frequency of heteropaternal superfecundation among dizygotic twins whose parents were involved in paternity suits was approximately 2.4%; see the references section, below, for more details.

Among monozygotic twins, in extremely rare cases, twins have been born with opposite sexes (one male, one female). The probability of this is so vanishingly small (only 3 documented cases) that multiples having different genders is universally accepted as a sound basis for a clinical determination that in utero multiples are not monozygotic. When monozygotic twins are born with different genders it is because of chromosomal birth defects. In this case, although the twins did come from the same egg, it is incorrect to refer to them as genetically identical, since they have different karyotypes.

Twinning in animals

Multiple births are common in many animal species, such as cats, sheep, and ferrets. The incidence of twinning among cattle is about 1-4%, and research is underway to improve the odds of twinning, which can be more profitable for the breeder if complications can be sidestepped or managed.


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The incidence of twinning among cattle is about 1-4%, and research is underway to improve the odds of twinning, which can be more profitable for the breeder if complications can be sidestepped or managed. During his tenure at the University of Miami, Jarrett wore his father's number, 34. Multiple births are common in many animal species, such as cats, sheep, and ferrets. His son, Jarrett, is currently an NFL running back, trying to carry on his father's legacy. In this case, although the twins did come from the same egg, it is incorrect to refer to them as genetically identical, since they have different karyotypes. Payton was survived by his wife Connie, son Jarrett, and daughter Brittany. When monozygotic twins are born with different genders it is because of chromosomal birth defects. After breaking Payton's career rushing record in 2002, Emmitt Smith tearfully paid tribute to Walter, saying that Payton had taught him how to conduct himself on and off the field.

The probability of this is so vanishingly small (only 3 documented cases) that multiples having different genders is universally accepted as a sound basis for a clinical determination that in utero multiples are not monozygotic. Unable to receive a liver transplant because of bile duct cancer, Payton died in his home in South Barrington, Illinois, on November 1, 1999. Among monozygotic twins, in extremely rare cases, twins have been born with opposite sexes (one male, one female). He didn't let his illness slow him down as he conducted many motivational speeches and appeared on TV encouraging organ donation. One 1992 study estimates that the frequency of heteropaternal superfecundation among dizygotic twins whose parents were involved in paternity suits was approximately 2.4%; see the references section, below, for more details. Living with unbearable pain, Walter continued to live his life the way he wanted to live it. This can lead to the possibility of a woman carrying fraternal twins with different fathers (that is, half-siblings). In February 1999, Payton announced that he had a rare liver disease called primary sclerosing cholangitis.

Among fraternal twins, in rare cases, the eggs are fertilised at different times with two or more acts of sexual intercourse, either within one menstrual cycle (superfecundation) or, even more rarely, later on in the pregnancy (superfetation). He also opened a restaurant and brewery in Aurora, Illinois called Walter Payton's Roundhouse Complex, which also contains a museum dedicated to Walter and his football career. There are some patterns of twinning that are exceedingly rare: while they have been reported to happen, they are so unusual that most obstetricians or midwives may go their entire careers without encountering a single case. A college preparatory high school in Chicago is named after him. Twins that have been separated early in life and raised in separate households are especially sought-after for these studies, which have been invaluable in the exploration of human nature. This effort, however, proved unsuccessful; the NFL instead awarded expansion franchises to Jacksonville, Florida and Charlotte, North Carolina in 1995. Twin studies are studies that assess identical (monozygotic) twins for medical, genetic, or psychological characteristics to try to isolate genetic influence from environmental influence. Louis.

Many fertility treatments have no effect on the likelihood of multiple births. After retirement, Payton dabbled in auto racing and was part of a group of investors that sought to bring an NFL team back to St. Some other treatments such as the drug Clomid can stimulate a woman to release multiple eggs, allowing the possibility of multiples. This tactic was considered to be an advantage to his team, perhaps gaining a few precious inches which would add up over the course of a game. With in vitro fertilisation (IVF), this is primarily due to the insertion of multiple embryos into the uterus. At the end of every carry, Payton would extend the ball as far forward as possible with his arms. This can vary depending on what types of fertility treatments are used. A few times, he leaped straight over a defender who was standing straight up for a touchdown.

Women undergoing certain fertility treatments may have a greater chance of multiple births. He was perhaps the most adept player at the "goal line leap" into the endzone. Dizygotic twin pregnancies are slightly more likely when the following factors are present in the woman:. He could often be seen with his hand on the facemask on a pursuing tackler, a tactic which would surely draw a penalty today. Some evidence suggests that the environment of the womb causes the zygote to split in most cases. His large leg muscles led to an unusual stiff-legged running gait, and he was not content to gain yards and run out of bounds. Fewer than 20 families have been described with an inherited tendency towards monozygotic twinning (people in these families have nearly a 50% chance of delivering monozygotic twins). At 5'-10", Payton wasn't a large man, nor was he a "breakaway" runner, but at a concrete-like 200 pounds, Payton's forte was power and quickness.

The cause of monozygotic twinning is unknown. Walter Payton's style of play was distinctive and memorable. Multiple pregnancies are usually delivered before the full term of 40 weeks gestation: the average length of pregnancy is around 36 weeks for twins, 34 weeks for triplets and 32 weeks for quadruplets. Coincidentally, Walter Payton's former teammate, Jeff Fisher, is the Titans' head coach. Before the advent of ovulation-stimulating drugs, triplets were quite rare (approximately 1 in 8000 births) and higher order births so rare as to be almost unheard of. His son Jarrett Payton, now a running back with the Tennessee Titans, gave his induction speech. If there are three, they are called triplets; four, quadruplets; five, quintuplets; six, sextuplets, seven, septuplets, and so on. On July 31, 1993, Payton was inducted into the Pro Football Hall of Fame.

Sometimes multiple births may involve more than two fetuses. While Payton only began playing football in his junior year of high school, Walter Payton retired with 16,726 yards, a total surpassed by the Dallas Cowboys' Emmitt Smith in 2002. Nevertheless, the rate of identical twins remains at about 1 in 250 across the globe, further suggesting that pregnancies resulting in identical twins occur randomly. Payton was visibly upset on the sideline about not being allowed to contribute more. Thus, approximately 6% of children born in the US in 2001 were twins. Some Bears fans believed that Mike Ditka insulted Payton by putting rookie phenomenon William "The Refrigerator" Perry, normally a defensive tackle, in at running back on a goal line play and giving him the ball. In 2001, for the first time ever in the US, the twinning rate exceeded 3% of all births. However sweet the victory was for the Chicago Bears and their fans, it turned out to be anything but sweet for Walter Payton, who rushed for only 61 yards in the game.

The widespread use of fertility drugs causing hyperovulation (stimulated release of multiple eggs by the mother) has caused what some call an "epidemic of multiple births". The Bears bounced back and finished strongly, then, augmented by a song Bears members recorded called The Super Bowl Shuffle, steamrolled through the NFC playoffs, shutting out both the New York Giants and the Los Angeles Rams, and finally defeating the New England Patriots 46-10 in Super Bowl XX where they limited the Patriots to 7 yards rushing, a Super Bowl record. The rate of twinning varies greatly among ethnic groups, ranging as high as about 6% for the Yoruba or 10% for a tiny Brazilian village (see [1]). In 1985, the Bears had an incredible season, going 15-1 in the regular season (with their only blemish being an embarrassing loss to the Miami Dolphins on Monday Night Football in the 13th week). Historically, about 1 in 80 human births (1.2%) has been the result of a twin pregnancy. Former Bears tight end Mike Ditka had returned to the team in 1982 as its head coach and began rebuilding it. Similar to vanishing twin. That changed in 1985.

Occasionally, a woman will suffer a miscarriage early in pregnancy, yet the pregnancy will continue; one twin was miscarried but the other was able to be carried to term. Although Walter Payton was a legitimate superstar and an icon in the city of Chicago, he played on some awful Bears teams. A chimera may arise either from identical twin fetuses (where it would be impossible to detect), or from dizygotic fetuses, which could be identified by chromosomal comparisons from various parts of the body. This consistency and toughness Walter exhibited was later chronicled in his autobiography, Never Die Easy. A chimera is a person who is a completely normal human with no extra parts, but some of the parts actually came from his or her twin. But perhaps more important to Walter than missing that game was the fact that he wanted to serve as an example to younger football players, and that he never took a play off and went all out every play. Sometimes the parasitic twin just becomes an almost indistinguishable part of the other. Walter insisted that he could have played.

One fetus acts as a parasite towards the other. Known as a figure of resilience, Payton only missed one game in his 13 year career with the Bears which took place during the 1975-76 season, Payton's rookie season, because the Bears trainer wouldn't allow Payton to play. Sometimes one twin fetus will fail to develop completely and continue to cause problems for its surviving twin. In one game against the Vikings on October 21, 1979, he ran for, passed for, and caught a touchdown, a feat that has only been done by six other players, most recently LaDainian Tomlinson of the San Diego Chargers. This condition occurs in about 1 in 100,000 pregnancies. In addition to being a Hall of Fame-caliber running back, Payton was assigned many plays as a receiver and blocker, and, later in his career, was also an emergency quarterback and punter. This occurs where the single zygote of identical twins fails to separate completely. Payton also scored 125 career touchdowns, seventh on the all-time scoring list.

Conjoined twins are monozygotic twins, whose bodies are joined together at birth. He was the NFL's Player of the Year and its Most Valuable Player in 1977. Early obstetric ultrasonography exams sometimes reveal an "extra" fetus, which fails to develop and instead disintegrates and vanishes. The 275 yards was an NFL single-game record until it was broken by Corey Dillon of the Cincinnati Bengals in 2001. Researchers suspect that more pregnancies start out as multiples than come to term that way. Against the Minnesota Vikings on November 20, 1977, Walter Payton rushed for 275 yards on 40 carries while fighting a severe case of influenza. Such conditions are usually associated with a higher incidence of other birth defects. His career rushing record would stand for 18 years until surpassed by Dallas Cowboys running back Emmitt Smith in 2002.

This is where some or all of the organs will be on the opposite side of the body, such as the heart being on the right(Dextrocardia). He also broke another Jim Brown record in this game with his 59th career 100-yard performance. One mirror may or may not have situs inversus. He earned numerous accomplishments, including his crowning achievement: breaking Jim Brown's NFL career rushing record against the New Orleans Saints at Soldier Field in Chicago on October 7, 1984. They result from a late split of the fertilized egg at around 9-12 days. Nicknamed "Sweetness," Payton was quiet, humble, and generous off the field, but a relentless, hard-nosed competitor on it. The incidence of mirror twinning is comparatively rare. The Bears drafted him in the first round (fourth overall) of the 1975 draft out of Jackson State University, where he was fourth in the voting for the Heisman Trophy (which was won that year by Ohio State University running back Archie Griffin, who would win it again the following year).

These are identical twins with opposite features, that is one may be right handed and the other may be left handed; hair will whorl in the opposite direction, and so on. Payton spent his entire 13-year career (1975-1987) with the Chicago Bears. Some percentage of monozygotic twins are called "mirror twins" or mirror image twins. . (Fraga, et al., 2005). Walter Jerry Payton (July 25, 1954- November 1, 1999) was an American football running back and is a member of the Pro Football Hall of Fame in Canton, Ohio. Twins who had spent their lives apart (such as those adopted by two different sets of parents at birth) had the greatest difference.

50-year-old twins had over 3 times the epigenetic difference that the 3-year-old twins had. The number of differences between identical twins increases with age. A study of 80 pairs of twins ranging in age from 3 to 74 showed that the youngest twins have relatively few epigenetic differences. This is called epigenetic modification.

Identical twins have identical DNA but differing environmental influences throughout their lives affect which genes are switched on or off. There are usually obvious signs of differences when the identical twins are observed separately or together. Twins are unique individuals that establish their own individual likes and dislikes. Many identical twins spend most of their time together (especially as children), so people often assume that they will behave alike just as they look alike; however, this is not the case.

They develop their own individual personalities to enable themselves to be identified as individual persons. Identical twins can behave as differently as any other siblings (a matter of much interest to psychologists). The exact cause for the splitting of a zygote or embryo is unknown. While it was originally thought that identical twins do not run in families, but occur more or less randomly, some recent research has suggested that a genetic predisposition may exist.

As they mature, identical twins often become less alike because of lifestyle choices or external influences such as scars. Examination of details such as fingerprints can tell them apart. (On extremely rare occasions, an original XXY zygote may form monozygotic boy/girl twins by dropping the Y chromosome for one twin and the extra X chromosome for the other.) Monozygotic twins generally look alike, although sometimes they appear as mirror images of each other. Monozygotic twins are genetically identical unless there has been a mutation in development, and they are almost always the same gender.

About 50% of mono-mono twins die from umbilical cord entanglement. These twins may develop such that blood passes disproportionately from one twin to the other through connecting blood vessels within their shared placenta, leading to twin-to-twin transfusion syndrome. Monochorionic twins, sharing one placenta, usually also share the placental blood supply. For example, the umbilical cords of monoamniotic twins can become entangled, reducing or interrupting the blood supply to the developing fetus.

Sharing the same amnion (or the same amnion and placenta) can cause complications in pregnancy. Twinning after 12 days post-fertilization will typically result in conjoined twins. Twinning between 8 to 12 days after fertilization will usually result in monochorionic-monoamniotic ("mono-mono") twins. Twinning between 4 to 8 days after fertilization typically results in monochorionic-diamniotic ("mono-di") twins.

Zygotes that twin at the earliest stages will be diamniotic and dichorionic ("di-di"). The later in pregnancy that twinning occurs, the more structures will be shared. This condition does not occur for fraternal twins. Also note that any monochorionic or monoamniotic twins are identical twins.

All monoamniotic twins are monochorionic. Diamniotic identical twins may share the same placenta (known as monochorionic) or not (dichorionic). Depending on the stage at which the zygote divides, identical twins may share the same amnion (in which case they are known as monoamniotic) or not (diamniotic). The two embryos develop into fetuses sharing the same womb.

Identical twins occur when a single egg is fertilized to form one zygote (monozygotic) but the zygote then divides into two separate embryos. However, it is only the female that has any influence on the chances of having fraternal twins as the male cannot make her release more than one ovum. Studies show that there is a genetic basis for fraternal twinning—that is, non-identical twins do run in families. Dizygotic twins may be a different sex or the same sex, just as with any other siblings.

Dizygotic twins, like any siblings, have a very small chance of having the exact same chromosome profile, but most likely have a number of different chromosomes that distinguish them. The two eggs form two zygotes, and these twins are therefore also known as dizygotic as well as "biovular" twins. Fraternal twins (commonly known as "non-identical twins") usually occur when two fertilized eggs are implanted in the uterine wall at the same time. .

Since some premature births often have health consequence to the babies, twins birth are often handled with special procedures. Due to the limited size of the mother's womb, multiple pregnancy is much less likely to carry to full term than singleton birth (twins usually around 34 to 36 weeks). A fetus alone in the womb is called a singleton. The term twin most notably refers to two individuals (or one of two individuals) who have shared the same uterus (womb) and are usually, but not necessarily, born on the same day.

Several previous pregnancies. Greater than average height and weight. Between the age of 30 and 40 years. She is of African descent.