Nelson MandelaNelson MandelaNelson Rolihlahla Mandela (born July 18, 1918), was the first democratically elected President of South Africa, having previously been a prominent anti-apartheid activist there. Initially committed to non-violence, he later became a guerrilla leader and was involved in the planning of underground armed resistance activities, such as sabotage. Mandela's 27-year imprisonment, much of which he spent in a tiny prison cell on Robben Island, became one of the most widely publicised examples of apartheid's injustices. Upon his release in 1990, the policy of reconciliation he pursued enabled a peaceful transition to a new, democratic South Africa - an enormous achievement which many South Africans believe would have been impossible without his influence. Despite controversy surrounding him, Mandela is one of the most celebrated and respected people of modern times, having received over a hundred awards over four decades. He is in his 80s, yet he still continues to voice his opinion on controversial issues, while enjoying the prestige accorded to him as an elder statesman. In South Africa he is known as Madiba, an honorary title adopted by elders of Mandela's clan. The title has come to be synonymous with Nelson Mandela. Early lifeNelson Mandela was born to a Xhosa family on July 18, 1918 in the village of Tembu, situated on the banks of the Mbashe River in the Transkei. He then moved to Qunu where he lived until he was 9 years old. His father was Hendry Mphakanyiswa Gadla, chief of Tembu. At the age of 7, Rolihlahla Mandela became the first member of his family to attend school, where he was given the name "Nelson" by a Methodist teacher. His father died when he was 10, and Nelson attended a Wesleyan mission school next door to the palace of the Regent. Following Xhosa custom, he was initiated at age 16, and attended Clarkebury Boarding Institute, learning about Western culture. He completed his Junior Certificate in two years, instead of the usual three. At age 16, in 1934, Mandela moved to the Wesleyan College in Fort Beaufort, which most Thembu royalty attended, and took an interest in boxing and running. After matriculating, he started with his B.A. at the Fort Hare University, where he met Oliver Tambo, and the two became lifelong friends and colleagues. At the end of his first year, he became involved in a boycott of the Students' Representative Council against the university policies, and was asked to leave Fort Hare. He left for Johannesburg, where he completed his degree at the University of South Africa (UNISA) via correspondence, after which he started with his law studies at the University of Witwatersrand. Political activityAs a young student, Mandela became involved in political opposition to the white minority government's denial of political, social, and economic rights to South Africa's black majority. Joining the African National Congress in 1942, he founded its more dynamic Youth League two years later, together with Walter Sisulu, Oliver Tambo and others. After the 1948 election victory of the Afrikaner-dominated National Party with its apartheid policy of racial segregation, Mandela was prominent in the ANC's 1952 Defiance Campaign and the 1955 Congress of the People, whose adoption of the Freedom Charter provided the fundamental program of the anti-apartheid cause. During this time, Mandela and fellow lawyer Oliver Tambo operated the law firm of Mandela and Tambo, providing free or low-cost legal counsel to many blacks who would otherwise have been without legal representation. Initially committed to non-violent mass struggle, he and 150 others were arrested on 5 December 1956, and charged with treason. The marathon Treason Trial of 1956–61 followed, and all were acquitted. After the Sharpeville Massacre in March 1960, coupled with the subsequent banning of the ANC and other anti-apartheid groups, Mandela and his colleagues decided on a course of armed action in order to effect change. Arrest and imprisonmentIn 1961, he became the leader of the ANC's armed wing Umkhonto we Sizwe (translated as Spear of the Nation, also abbreviated MK), which he co-founded. He coordinated a sabotage campaign against military, government and civilian targets, and made plans for a possible guerrilla war if sabotage failed to end apartheid. He also raised funds for MK abroad, and arranged for paramilitary training, visiting various African governments. On August 5, 1962, he was arrested after living on the run for seventeen months and was imprisoned in the Johannesburg Fort. There was some speculation, as yet unproven, that the CIA might have tipped off the police as to his whereabouts. Three days later, the charges of leading workers to strike in 1961 and leaving the country illegally were read to him during a court appearance. On October 25, 1962, Mandela was sentenced to five years in prison. Two years later on June 11, 1964, a verdict had been reached concerning his previous engagement in the African National Congress. While Mandela was in prison, police arrested prominent ANC leaders on July 11, 1963, at Liliesleaf Farm, Rivonia, north of Johannesburg. Mandela was brought in, and at the Rivonia Trial, Mandela, Ahmed Kathrada, Walter Sisulu, Govan Mbeki, Andrew Mlangeni, Raymond Mhlaba, Elias Motsoaledi, Walter Mkwayi (who escaped during trial), Arthur Goldreich (who escaped from prison before trial), Dennis Goldberg and Lionel "Rusty" Bernstein were charged with sabotage and crimes equivalent to treason, but which were easier for the government to prove. Joel Joffe, Arthur Chaskalson and George Bizos were part of the defense team that represented the accused. All except Rusty Bernstein were found guilty and sentenced to life imprisonment on 12 June 1964. Charges included involvement in planning armed action, in particular sabotage, which Mandela admitted to, and a conspiracy to help other countries invade South Africa, which Mandela denied. Over the course of the next twenty-six years, Mandela became increasingly associated with opposition to apartheid to the point where the slogan "Free Nelson Mandela" became the rallying cry for all anti-apartheid campaigners around the world. While in prison, Mandela was able to send a statement to the ANC who in turn published it on 10 June 1980, reading in part: Unite! Mobilise! Fight on! Between the anvil of united mass action and the hammer of the armed struggle we shall crush apartheid! [1] Refusing an offer of conditional release in return for renouncing armed struggle in February 1985, Mandela remained in prison until February 1990, when sustained ANC campaigning and international pressure led to his release on February 11, when State President F.W. de Klerk ordered his release and the ending of the ban on the ANC. He and De Klerk shared the Nobel Peace Prize in 1993. He became the third of only three persons of non-Indian origin (Mother Teresa in 1980, a naturalized Indian citizen, and Khan Abdul Ghaffar Khan in 1987, a non-Indian, being the others) to be awarded the Bharat Ratna, India's highest civilian award, in 1990. Mandela had already been awarded the Sakharov Prize for Freedom of Thought in 1988. On the day of his release, February 11, 1990, Mandela made a speech to the nation. While declaring his commitment to peace and reconciliation with the country's white minority, he made it clear that the ANC's armed struggle was not yet over:
ANC presidency and presidency of South AfricaSouth Africa's first democractic elections were held on April 27, 1994. The ANC won a landslide victory, and Mandela, as leader of the ANC, was inaugurated as the country's first black State President, with the National party's FW de Klerk as his deputy president in the Government of National Unity. As President, (May 1994 – June 1999), Mandela presided over the transition from minority rule and apartheid, winning international respect for his advocacy of national and international reconciliation. Some radicals were disappointed with the social achievements of his term of office, particularly the government's ineffectiveness in stemming the AIDS crisis. After his retirement, Mandela admitted that he may have failed his country by not paying more attention to the HIV/AIDS epidemic. He has taken many opportunities since to highlight this South African tragedy. MarriagesMandela has been married three times. His first marriage to Evelyn Ntoko Mase ended in divorce in 1957 after 13 years, and his 38-year marriage to Winnie Madikizela ended in separation (April 1992) and divorce (March 1996), fueled by political estrangement. On his 80th birthday, he married Graça Machel, widow of Samora Machel, the former Mozambican president and ANC ally killed in an air crash 15 years earlier. RetirementFormer United States Vice President Al Gore meets with Mandela.After his retirement as President in 1999, Mandela went on to become an advocate for a variety of social and human rights organisations. He received many foreign honours, including the Order of St. John from Queen Elizabeth II and the Presidential Medal of Freedom from George W. Bush. As an example of his popular acclaim, in his tour of Canada in 1998, he included a speaking engagement in SkyDome in the city of Toronto where he spoke to 45,000 school children who greeted him with intense adulation. In 2001, he was the first living foreigner to be made an honourary Canadian citizen (the first, Raoul Wallenberg, was posthumously made a Canadian citizen) as well as being one of the few foreign leaders to receive the Order of Canada. In 2003, Mandela attacked the foreign policy of the George W. Bush administration in a number of speeches, going so far as calling Bush a racist for not following the UN and its secretary-general Kofi Annan (who is African) on the issue of the War in Iraq. "Is it because the secretary-general of the United Nations is now a black man? They never did that when secretary-generals were white," Mandela said.[2] The comments caused a rare moment of controversy and criticism for Mandela, even among some supporters. Later that same year, he lent his support to the 46664 AIDS fundraising campaign, named after his prison number. In June 2004 at age 85, Mandela announced that he would be retiring from public life. His health had been declining, and he wanted to enjoy more time with his family. He has made an exception, however, for his commitment to the fight against AIDS. In July 2004, he flew to Bangkok to speak at the XV International AIDS Conference. His eldest son, Makgatho Mandela, died of AIDS on 6 January 2005. [3] Mandela has also expressed his support for the ONE Campaign, which forms part of the international Make Poverty History movement. On July 23, 2004, the city of Johannesburg bestowed its highest honour on Mandela by granting him the freedom of the city at a ceremony in Orlando, Soweto. In 2005, Mandela became embroiled in a legal dispute with his former lawyer, Ismail Ayob, and others, who were accused of exploiting Mandela's name and reputation. The dispute revolves around the promotion and sale of allegedly fraudulent artworks bearing Mandela's name. The works commanded high prices on the international art market, but they are now widely regarded as being devoid of any real value. Today, Mandela remains a key figure to strong educational organizations that hold his ideals strongly of international understanding and peace, like the United World Colleges and the Round Square. Orders and decorations
See also the List of awards bestowed on Nelson Mandela. OtherMandela is known for his fondness of Batik textiles. He is often seen wearing Batik, even on formal occasions. Shirts in this style are fondly known as "Madiba shirts" in South Africa. In 2003, Mandela's death was incorrectly announced by CNN when his pre-written obituary (along with those of several other famous figures) was inadvertently published on CNN's web site due to a lapse in password protection. Courtroom quotes
Further reading
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Mandela is known for his fondness of Batik textiles. “We do not know… uncertain… not too far out… we do not know for certain… we suspect… chances are…” And thus the Nobel prize winner embraces the theory that space aliens sent rocketships to seed the earth. See also the List of awards bestowed on Nelson Mandela. They can be stored almost indefinitely at very low temperatures, and the chances are they would multiply easily in the ‘soup’ of the primitive ocean…'. Today, Mandela remains a key figure to strong educational organizations that hold his ideals strongly of international understanding and peace, like the United World Colleges and the Round Square. Since they are small, many of them can be sent. The works commanded high prices on the international art market, but they are now widely regarded as being devoid of any real value. For such a job, bacteria are ideal. The dispute revolves around the promotion and sale of allegedly fraudulent artworks bearing Mandela's name. Could life have first started much earlier on the planet of some distant star, perhaps eight to 10 billion years ago? If so, a higher civilization, similar to ours, might have developed from it at about the time that the Earth was formed… Would they have had the urge and the technology to spread life through the wastes of space and seed these sterile planets, including our own?.. In 2005, Mandela became embroiled in a legal dispute with his former lawyer, Ismail Ayob, and others, who were accused of exploiting Mandela's name and reputation. Although we do not know for certain, we suspect that there are in the galaxy many stars with planets suitable for life…. On July 23, 2004, the city of Johannesburg bestowed its highest honour on Mandela by granting him the freedom of the city at a ceremony in Orlando, Soweto. Its exact age is uncertain but a figure of 10 to 15 billion years is not too far out…. Mandela has also expressed his support for the ONE Campaign, which forms part of the international Make Poverty History movement. The universe began much earlier. [3]. Exactly how it started we do not know…. His eldest son, Makgatho Mandela, died of AIDS on 6 January 2005. As he put it, bouncing along a tenuous chain of probabilities: 'The first self-replicating system is believed to have arisen spontaneously in the ‘soup,’ the weak solution of organic chemicals formed in the oceans, seas, and lakes by the action of sunlight and electric storms. In July 2004, he flew to Bangkok to speak at the XV International AIDS Conference. Concerned by the narrow time frame – to those of a non-creationist bent - between the cooling of the earth and the rapid emergence of the planet’s first life forms, Crick determined to provide another explanation for the origin of life. He has made an exception, however, for his commitment to the fight against AIDS. As the key to the mystery of life, DNA seems a small answer to the big picture, so Crick pushed on, advancing the theory of “Directed Panspermia”, which is not a Clinton DNA joke but his and his colleague Leslie Orgel’s explanation for how life began. His health had been declining, and he wanted to enjoy more time with his family. To quote political analyst Mark Steyn, "His militant atheism was good-humoured but fierce, and it drove him away from molecular biology. In June 2004 at age 85, Mandela announced that he would be retiring from public life. At 12, Crick decided he was an atheist[14] and spent much of the rest of his life trying to disprove the existence of the psyche. Later that same year, he lent his support to the 46664 AIDS fundraising campaign, named after his prison number. His personality combined with his scientific accomplishments produced many opportunities for Crick to stimulate reactions from others, both inside and outside of the scientific world that was the center of his intellectual and professional life. "Is it because the secretary-general of the United Nations is now a black man? They never did that when secretary-generals were white," Mandela said.[2] The comments caused a rare moment of controversy and criticism for Mandela, even among some supporters. Crick has widely been described as talkative, brash and lacking modesty. Bush administration in a number of speeches, going so far as calling Bush a racist for not following the UN and its secretary-general Kofi Annan (who is African) on the issue of the War in Iraq. Kari Olcott RN was his nurse at the time. In 2003, Mandela attacked the foreign policy of the George W. Crick died of colon cancer at The University of California, San Diego Thornton Hospital, San Diego. In 2001, he was the first living foreigner to be made an honourary Canadian citizen (the first, Raoul Wallenberg, was posthumously made a Canadian citizen) as well as being one of the few foreign leaders to receive the Order of Canada. He was elected a fellow of CSICOP in 1983 and a Humanist Laureate of the International Academy of Humanism in the same year. As an example of his popular acclaim, in his tour of Canada in 1998, he included a speaking engagement in SkyDome in the city of Toronto where he spoke to 45,000 school children who greeted him with intense adulation. Starting in 1976, Crick worked at the Salk Institute in La Jolla, California. Bush. In 1995, Francis Crick was also one of the original endorsers of the Ashley Montagu Resolution to petition for an end to the genital mutilations of children. John from Queen Elizabeth II and the Presidential Medal of Freedom from George W. He was a well-known atheist who also advocated directed panspermia as a hypothesis for how life started on Earth. He received many foreign honours, including the Order of St. Crick's book The Astonishing Hypothesis makes the argument that neuroscience now has the tools required to begin a scientific study of how brains produce conscious experiences. After his retirement as President in 1999, Mandela went on to become an advocate for a variety of social and human rights organisations. His autobiographical book What Mad Pursuit includes a description of why he left molecular biology and switched to neuroscience. On his 80th birthday, he married Graça Machel, widow of Samora Machel, the former Mozambican president and ANC ally killed in an air crash 15 years earlier. He later left molecular biology for his other interest, consciousness. His first marriage to Evelyn Ntoko Mase ended in divorce in 1957 after 13 years, and his 38-year marriage to Winnie Madikizela ended in separation (April 1992) and divorce (March 1996), fueled by political estrangement. Crick's view of the realationship between science and religion would continue to play a role in his work as he made the transition from molecular biology research into theoretical neuroscience. Mandela has been married three times. Crick's suggestion that there might some day be a new science of "biochemical theology" seems to have been realized under an alternative name, there is now the new field of Neurotheology[13]. He has taken many opportunities since to highlight this South African tragedy. Crick may have been imagining substances such as dopamine that are released by the brain under certain conditions and produce rewarding sensations. After his retirement, Mandela admitted that he may have failed his country by not paying more attention to the HIV/AIDS epidemic. He speculated that there might be a detectable change in the level of some neurotransmitter or neurohormone when people pray. Some radicals were disappointed with the social achievements of his term of office, particularly the government's ineffectiveness in stemming the AIDS crisis. Crick suggested that it might be possible to find chemical changes in the brain that were molecular correlates of the act of prayer. As President, (May 1994 – June 1999), Mandela presided over the transition from minority rule and apartheid, winning international respect for his advocacy of national and international reconciliation. Crick wrote, "So many people pray that one finds it hard to believe that they do not get some satisfaction from it....". The ANC won a landslide victory, and Mandela, as leader of the ANC, was inaugurated as the country's first black State President, with the National party's FW de Klerk as his deputy president in the Government of National Unity. He also discussed what he described as a possible new direction for research, what he called "biochemical theology". South Africa's first democractic elections were held on April 27, 1994. Near the end of the article, Crick briefly mentioned the search for life on other planets, but he held little hope that extraterrestrial life would be found by the year 2000. While declaring his commitment to peace and reconciliation with the country's white minority, he made it clear that the ANC's armed struggle was not yet over:. His speculations were later published in Nature[12]. On the day of his release, February 11, 1990, Mandela made a speech to the nation. Crick attempted to make some predictions about what the next 30 years would hold for molecular biology. Mandela had already been awarded the Sakharov Prize for Freedom of Thought in 1988. In October 1969, Crick participated in a celebration of the 100th year of the journal Nature. He became the third of only three persons of non-Indian origin (Mother Teresa in 1980, a naturalized Indian citizen, and Khan Abdul Ghaffar Khan in 1987, a non-Indian, being the others) to be awarded the Bharat Ratna, India's highest civilian award, in 1990. The details of the code came mostly from work by Marshall Nirenberg and others who synthesized synthetic RNA molecules and used them as templates for in vitro protein synthesis[11]. He and De Klerk shared the Nobel Peace Prize in 1993. Proof that the genetic code is a degenerate triplet code finally came from genetics experiments, some of which were performed by Crick[10]. de Klerk ordered his release and the ending of the ban on the ANC. Crick had by this time become a dominant, if not the dominant, theoretical molecular biologist. Refusing an offer of conditional release in return for renouncing armed struggle in February 1985, Mandela remained in prison until February 1990, when sustained ANC campaigning and international pressure led to his release on February 11, when State President F.W. Crick was focused on this third component (information) and it became the organizing principle of what became known as molecular biology. Unite! Mobilise! Fight on! Between the anvil of united mass action and the hammer of the armed struggle we shall crush apartheid! [1]. In his thinking about the biological processes linking DNA genes to proteins, Crick made explicit the distinction between the materials involved, the energy required and the information flow. While in prison, Mandela was able to send a statement to the ANC who in turn published it on 10 June 1980, reading in part:. Some critics thought that by using the word "dogma" Crick was implying that this was a rule that could not be questioned, but all he really meant was that it was a compelling idea without much solid evidence to support it. Over the course of the next twenty-six years, Mandela became increasingly associated with opposition to apartheid to the point where the slogan "Free Nelson Mandela" became the rallying cry for all anti-apartheid campaigners around the world. Crick also used the term “central dogma” to summarize an idea that implies that genetic information flow between macromolecules would be essentially oneway: All except Rusty Bernstein were found guilty and sentenced to life imprisonment on 12 June 1964. Crick also explored other codes in which for various reasons only some of the triplets were used, “magically” producing just the 20 needed combinations. Joel Joffe, Arthur Chaskalson and George Bizos were part of the defense team that represented the accused. Some amino acids might have multiple triplet codes. Mandela was brought in, and at the Rivonia Trial, Mandela, Ahmed Kathrada, Walter Sisulu, Govan Mbeki, Andrew Mlangeni, Raymond Mhlaba, Elias Motsoaledi, Walter Mkwayi (who escaped during trial), Arthur Goldreich (who escaped from prison before trial), Dennis Goldberg and Lionel "Rusty" Bernstein were charged with sabotage and crimes equivalent to treason, but which were easier for the government to prove. Such a code might be “degenerate”, with 4x4x4=64 possible triplets of the four nucleotide subunits while there were only 20 amino acids. While Mandela was in prison, police arrested prominent ANC leaders on July 11, 1963, at Liliesleaf Farm, Rivonia, north of Johannesburg. In his 1958 article, Crick speculated, as had others, that a triplet of nucleotides could code for an amino acid. Two years later on June 11, 1964, a verdict had been reached concerning his previous engagement in the African National Congress. None of this, however, answered the fundamental theoretical question of the exact nature of the genetic code. On October 25, 1962, Mandela was sentenced to five years in prison. An important step was later (1960) realization that the messenger RNA was not the same as the ribosomal RNA. Three days later, the charges of leading workers to strike in 1961 and leaving the country illegally were read to him during a court appearance. The “adaptor molecules” were eventually shown to be tRNAs and the catalytic “ribonucleic-protein complexes” became known as ribosomes. There was some speculation, as yet unproven, that the CIA might have tipped off the police as to his whereabouts. By 1958 Crick’s thinking had matured and he could list in an orderly way all of the key features of the protein synthesis process[9]. On August 5, 1962, he was arrested after living on the run for seventeen months and was imprisoned in the Johannesburg Fort. During the mid-to-late 50s Crick was very much intellectually engaged in sorting out the mystery of how proteins are synthesized. He also raised funds for MK abroad, and arranged for paramilitary training, visiting various African governments. He also explored the many theoretical possibilities by which short nucleic acid sequences might code for the 20 amino acids. He coordinated a sabotage campaign against military, government and civilian targets, and made plans for a possible guerrilla war if sabotage failed to end apartheid. Crick proposed that there was a corresponding set of small adaptor molecules that would hydrogen bond to short sequences of a nucleic acid and also link to one of the amino acids. In 1961, he became the leader of the ANC's armed wing Umkhonto we Sizwe (translated as Spear of the Nation, also abbreviated MK), which he co-founded. In this article, Crick reviewed the evidence supporting the idea that there was a common set of about 20 amino acids used to synthesize proteins. After the Sharpeville Massacre in March 1960, coupled with the subsequent banning of the ANC and other anti-apartheid groups, Mandela and his colleagues decided on a course of armed action in order to effect change. In 1956 Crick wrote an informal paper about the genetic coding problem for the small group of scientists in Gamow’s RNA group[8]. The marathon Treason Trial of 1956–61 followed, and all were acquitted. It was clear to Crick that there had to be a code by which a short sequence of nucleotides would specify a particular amino acid in a newly synthesized protein. Initially committed to non-violent mass struggle, he and 150 others were arrested on 5 December 1956, and charged with treason. George Gamow established a group of scientists who were interested in the role of RNA as an intermediary between DNA as the genetic storage molecule in the nucleus of cells and the synthesis of proteins in the cytoplasm. During this time, Mandela and fellow lawyer Oliver Tambo operated the law firm of Mandela and Tambo, providing free or low-cost legal counsel to many blacks who would otherwise have been without legal representation. However, Crick was quickly drifting away from continued work related to his expertise in the interpretation of X-ray diffraction patterns of proteins. After the 1948 election victory of the Afrikaner-dominated National Party with its apartheid policy of racial segregation, Mandela was prominent in the ANC's 1952 Defiance Campaign and the 1955 Congress of the People, whose adoption of the Freedom Charter provided the fundamental program of the anti-apartheid cause. Crick engaged in several X-ray diffraction collaborations such as one with Alexander Rich on the structure of collagen[7]. Joining the African National Congress in 1942, he founded its more dynamic Youth League two years later, together with Walter Sisulu, Oliver Tambo and others. After his short time in New York, Crick returned to Cambridge where he worked until moving to California in 1976. As a young student, Mandela became involved in political opposition to the white minority government's denial of political, social, and economic rights to South Africa's black majority. Crick then worked in the laboratory of David Harker at Brooklyn Polytechnic Institute where he continued to develop his skills in the analysis of X-ray diffraction data for proteins, working primarily on ribonuclease. He left for Johannesburg, where he completed his degree at the University of South Africa (UNISA) via correspondence, after which he started with his law studies at the University of Witwatersrand. thesis: "X-Ray Diffraction: Polypeptides and Proteins" and received his degree at the age of 37. At the end of his first year, he became involved in a boycott of the Students' Representative Council against the university policies, and was asked to leave Fort Hare. In 1953, Crick completed his Ph.D. at the Fort Hare University, where he met Oliver Tambo, and the two became lifelong friends and colleagues. In 1953, Watson and Crick published another article in ‘’Nature’’ which stated: “it therefore seems likely that the precise sequence of the bases is the code that carries the genetical information”[6]. After matriculating, he started with his B.A. After the discovery of the double helix model of DNA, Crick’s interests quickly turned to the biological implications of the structure. At age 16, in 1934, Mandela moved to the Wesleyan College in Fort Beaufort, which most Thembu royalty attended, and took an interest in boxing and running. This includes work on the nature of the genetic code and the mechanisms of protein synthesis. He completed his Junior Certificate in two years, instead of the usual three. Francis Crick also made significant contributions in laying the foundations of the now mature field of molecular biology. Following Xhosa custom, he was initiated at age 16, and attended Clarkebury Boarding Institute, learning about Western culture. The Watson and Crick discovery of the DNA double helix structure was made possible by their correct interpretation of the significance of experimental results that had been obtained by others. His father died when he was 10, and Nelson attended a Wesleyan mission school next door to the palace of the Regent. Crick did tentatively attempt to perform some experiments on nucleotide base pairing, but he was more of a theoretical biologist than one who would perform experiments. At the age of 7, Rolihlahla Mandela became the first member of his family to attend school, where he was given the name "Nelson" by a Methodist teacher. As important as Crick’s contributions to the discovery of the double helical DNA model were, he stated that without the chance to collaborate with Watson, he would not have found the structure by himself. His father was Hendry Mphakanyiswa Gadla, chief of Tembu. After the discovery of the A:T and C:G pairs, Watson and Crick soon had their double helix model of DNA with the hydrogen bonds at the core of the helix providing a way to unzip the two complementary strands for easy replication: the last key requirement for a likely model of the genetic molecule. He then moved to Qunu where he lived until he was 9 years old. Watson’s recognition of the A:T and C:G pairs was aided by information from Jerry Donohue[5] about the likely structures of the nucleotides. Nelson Mandela was born to a Xhosa family on July 18, 1918 in the village of Tembu, situated on the banks of the Mbashe River in the Transkei. The base pairs are held together by hydrogen bonds, the same non-covalent interaction that stabilizes the protein α helix. . In particular, the length of each base pair is the same. The title has come to be synonymous with Nelson Mandela. The significance of these ratios for the structure of DNA were not recognized until Watson, persisting in building structural models, realized that A:T and C:G pairs are structurally similar. In South Africa he is known as Madiba, an honorary title adopted by elders of Mandela's clan. A visit by Erwin Chargaff to England in 1952 helped keep this important fact in front of Watson and Crick. He is in his 80s, yet he still continues to voice his opinion on controversial issues, while enjoying the prestige accorded to him as an elder statesman. Another key to finding the correct structure of DNA was the so-called Chargaff ratios, experimentally determined ratios of the nucleotide subunits of DNA: the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine. Despite controversy surrounding him, Mandela is one of the most celebrated and respected people of modern times, having received over a hundred awards over four decades. Watson and Crick made use of information from unpublished X-ray diffraction images (shown at meetings, described by Wilikins, and included in administrative progress reports) to determine some basic features of the DNA helical structure such as some key dimensions and the fact that there were anti-parallel chains. Upon his release in 1990, the policy of reconciliation he pursued enabled a peaceful transition to a new, democratic South Africa - an enormous achievement which many South Africans believe would have been impossible without his influence. Crick described the failure of Maurice Wilkins and Rosalind Franklin to cooperate and work towards finding a molecular model as a major reason why he and Watson persisted in their efforts. Mandela's 27-year imprisonment, much of which he spent in a tiny prison cell on Robben Island, became one of the most widely publicised examples of apartheid's injustices. Having failed once, Watson and Crick were now somewhat reluctant (for a while Crick was ‘’forbidden’’) to make further efforts to find a molecular model of DNA. Initially committed to non-violence, he later became a guerrilla leader and was involved in the planning of underground armed resistance activities, such as sabotage. thesis and Watson was supposed to be trying to obtain crystals of myoglobin for X-ray diffraction experiments. Nelson Rolihlahla Mandela (born July 18, 1918), was the first democratically elected President of South Africa, having previously been a prominent anti-apartheid activist there. Crick was writing his Ph.D. Nelson Mandela; Long Walk to Freedom: The Autobiography of Nelson Mandela; Little Brown & Co; ISBN 0-3165-4818-9 (paperback, 1995). Watson and Crick were not officially working on DNA. Anthony Sampson; Mandela: the authorized biography; ISBN 0-6797-8178-1 (1999). They knew they were competing against Pauling and feared that as for the protein α helix, Pauling would probably again win the race to discover the structure of DNA. Freedom of the City of Johannesburg (2004). Crick and Watson produced and showed off an erroneous first model of DNA that mainly served to show how little they knew and how desperate they were to solve the structure of DNA. Order of Merit (1995). Watson and Crick talked endlessly about DNA and the idea that it might be possible to guess a good molecular model of its structure. Bharat Ratna (1990). The images indicated to Crick, one of the few experts in helical diffraction theory, that DNA had a helical structure. Lenin Peace Prize (1962). A key piece of experimentally-derived information came from X-ray diffraction images that had been obtained by Maurice Wilkins and his student, Raymond Gosling. Presidential Medal of Freedom. They shared an interest in the fundamental problem of learning how genetic information might be stored in molecular form. John. When James Watson came to Cambridge, Crick was a 35 year old graduate student and Watson was only 23, but already had a Ph.D. Order of St. Building on the X-ray diffraction results of Maurice Wilkins, Raymond Gosling and Rosalind Franklin, they together developed the proposal of the helical structure of DNA, which they published in 1953[3], and for which they were awarded the Nobel Prize in Physiology or Medicine in 1962, together with Maurice Wilkins of University College, London[4]. Honorary Companion of The Order of Canada. Watson at Cavendish Laboratory at the University of Cambridge in England. Nobel Peace Prize (1993). In 1951, he started working with James D. For example, he learned the importance of the structural rigidity that double bonds confer on molecular structures which is relevant both to peptide bonds in proteins and the structure of nucleotides in DNA. Crick was witness to the kinds of errors that his co-workers made in their failed attempts to make a correct molecular model of the α helix, these turned out to be important lessons that could be applied to the helical structure of DNA. Pauling was the first to identify the 3.6 amino acids/turn ratio of the α helix. During this time when Crick was learning about X-ray diffraction, researchers in the Cambridge lab were attempting to determine the most stable helical conformation of amino acid chains in proteins (the α helix). This theoretical result matched well with X-ray data obtained for proteins that contain sequences of amino acids in the Alpha helix conformation (published in Nature in 1952)[2]. Vand he worked out a mathematical theory of X-ray diffraction by a helical molecule. Cochran and V. Together with W. Crick taught himself the mathematical theory of X-ray crystallography. X-ray crystallography theoretically offered the opportunity to reveal the molecular structure of proteins, but there were serious technical problems then preventing X-ray crystallography from being applicable to such large molecules. Crick was in the right place, in the right frame of mind, at the right time (1949) to join Max Perutz’s project at Cambridge University, and he began to work on the X-ray crystallography of proteins. However, other evidence was interpreted as suggesting that DNA was structurally uninteresting and possibly just a molecular scaffold for the apparently more interesting protein molecules. Oswald Avery and his collaborators showed that a phenotypic difference could be caused in bacteria by providing them with a particular DNA molecule. In the 1940’s some evidence had been found pointing to another biological molecule, DNA, the other major component of chromosomes, as a candidate genetic molecule. However, it was well known that proteins are “doers”, macromolecules that carry out the many enzymatic reactions of cells. It was clear that some macromolecule such as protein was likely to be the genetic molecule. In Crick’s view, Charles Darwin’s theory of evolution by natural selection, Gregor Mendel’s genetics and knowledge of the molecular basis of genetics, when combined, reveal the secret of life. It only remained as an exercise of experimental biology to discover exactly which molecule was the genetic molecule. It was clear in theory that covalent bonds in biological molecules could provide the structural stability needed to hold genetic information in cells. It was at this time of Crick’s transition from physics into biology that he was influenced by both Linus Pauling and Erwin Schroedinger. He realized that his background made him more qualified for research on the first topic and the field of biophysics. First, how molecules make the transition from the non-living to the living, and second, how the brain makes mind. Crick was interested in two fundamental unsolved problems of biology. Crick felt that this attitude encouraged him to be more daring than typical biologists who mainly concerned themselves with the daunting problems of biology and not the past successes of physics. Crick had to adjust from the “elegance and deep simplicity” of physics to the “elaborate chemical mechanisms that natural selection had evolved over billions of years.” He described this transition as, “almost as if one had to be born again.” According to Crick, the experience of learning physics had taught him something important -hubris- and the conviction that since physics was already a success, great advances should also be possible in other sciences like biology. This migration was made possible by the newly won influence of physicists such as John Randall who had helped win the war with inventions like radar. After the war, Crick became part of an important migration of physical scientists into Biology research. Andrade but with the outbreak of World War II, Crick was deflected from a possible career in physics. da C. N. research project in the laboratory of E. Crick began a Ph.D. degree in physics in from University College London. At the age of 21, Crick earned a B.Sc. He was educated at Northampton Grammar School and, after the age of 14, Mill Hill School in London (on scholarship) where he learned mathematics, physics and chemistry. Crick preferred the scientific search for answers over belief in any traditional religious dogma. As a child he was taken to church (Congregationalist) by his parents, but by about age 12 he told his mother that he no longer wanted to attend[1]. At an early age he was attracted to science and what he could learn about it from books. Crick was born and raised in the town of Northampton where Crick’s father and uncle ran the family’s shoe factory. He began studying biology in 1947 after the war's end. During World War II, he worked on magnetic and acoustic mines. in 1937. Born in Northampton, England as a son of Harry Crick and Annie Elisabeth Crick, he studied physics at University College London, and became a B.Sc. . Professor Francis Harry Compton Crick, OM FRS (June 8, 1916 – July 28, 2004) was a British physicist, molecular biologist and neuroscientist, most noted for being one of the discoverers of the structure of the DNA molecule. Watson (Mitchell Lane Publishers, Inc., 2002) ISBN 1584151226. Francis Crick and James Watson: Pioneers in DNA Research by John Bankston, Francis Crick and James D. The book also formed the basis of the award winning television dramatisation Life Story by BBC Horizon (also broadcast as Race for the Double Helix). Watson, The Double Helix: A Personal Account of the Discovery of the Structure of DNA, Atheneum, 1980, ISBN 0689706022 (first published in 1968) is a very readable first hand account of the research by Crick and Watson. James D. Edward Edelson, Francis Crick And James Watson: And the Building Blocks of Life Oxford University Press, 2000, ISBN 0195139712. The Astonishing Hypothesis: The Scientific Search For The Soul (Scribner reprint edition, 1995) ISBN 0684801582. Of Molecules and Men (Prometheus Books, 2004; original edition 1967) ISBN 1591021855. Life Itself (Simon & Schuster, 1981) ISBN 0671255622. ^ Online at hallucinogens.com: Nobel Prize genius Crick was high on LSD when he discovered the secret of life by Alun Rees. Crick's description of his religious views (as given in What Mad Pursuit, see Chapter 1 of reference #1, above) after having told his mother that he no longer wished to attend church services: "...from then on I was a skeptic, an agnostic with a strong inclination toward atheism.". ^ See The Twentieth-Century Darwin by Mark Steyn published in The Atlantic Monthly October 2004. Entrez PubMed 14594742. Farde in The American Journal of Psychiatry (2003) Volume 160, pages 1965-1969. Soderstrom and L. Andree, H. Borg, B. ^ "The serotonin system and spiritual experiences" by J. ^ "Molecular Biology in the Year 2000" by Francis Crick in Nature Volume 228 (1970) pages 613-615. Crick in Proc R Soc Lond B Biol Sci. (1967) Volume 167 pages 331-347. H. The genetic code" by F. ^ "The Croonian lecture, 1966. Watts-Tobin in Nature (1961) Volume 192 pages 1227-1232. J. Brenner and R. Barnett, S. Crick, L. H. ^ "General nature of the genetic code for proteins" by F. Crick in Symp Soc Exp Biol. (1958);12:138-63. H. ^ "On protein synthesis" by F. ^ "On Degenerate Templates and the Adaptor Hypothesis: A Note for the RNA Tie Club" by Francis Crick (1956). Crick in Nature (1955) Volume 176, pages 915-916. H. ^ "The structure of collagen" by A Rich and F. Crick (1953) in Nature Volume 171 pages 964-967. H. Watson and F. D. ^ "Genetical implications of the structure of deoxyribonucleic acid" by J. ^ See Chapter 3 of The Eighth Day of Creation: Makers of the Revolution in Biology by Horace Freeland Judson published by Cold Spring Harbor Laboratory Press (1996) ISBN 0879694785. ^ Francis Crick's 1962 Biography from the Nobel foundation. Nature 171, 737–738 (1953). Crick. Watson and Francis H. ^ Molecular structure of Nucleic Acids by James D. Crick's scientific publications and letters are in the list of Francis Crick's Papers from the Wellcome Library at the National Library of Medicine. ^ See "Evidence for the Pauling-Corey alpha-Helix in Synthetic Polypeptides" (1952) Nature Volume 169 pages 234-235 (download PDF). ^ Chapters 1 and 2 of What Mad Pursuit: A Personal View of Scientific Discovery by Francis Crick (Basic Books reprint edition, 1990 ISBN 0465091385) provide Crick's description of his early life and education. ribonucleic-protein complexes that catalyze the assembly of amino acids into proteins according to the messenger RNA. adaptor molecules (“they might contain nucleotides”) to match short sequences of nucleotides in the RNA messenger molecules to specific amino acids. a “messenger” RNA molecule to carry the instructions for making one protein to the cytoplasm. genetic information stored in the sequence of DNA molecules. |