Gregory Goodwin Pincus

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Gregory Goodwin Pincus (April 9, 1903 - August 22, 1967), American physician, biologist, and researcher, was co-inventor of the contraceptive pill. Pincus began studying hormonal biology and steroidal hormones early in his career. He was instrumental in persuading Searle to fund this research, at a time when Pfizer and Parke-Davis were reluctant to fund human trials.

Pincus's first breakthrough came early, when he was able to produce in vitro fertilization in rabbits in 1934.

His experiments involving parthenogenesis produced a rabbit that appeared on the cover of Look magazine in 1937 and led to his dismissal from Harvard University.

In 1953, Margaret Sanger and Katherine McCormick sought out Pincus for a project involving contraception. Pincus, along with Min-Chueh Chang, investigated and established that progesterone would act as an inhibitor to ovulation. However, despite early success in preventing ovulation, and therefore fertilization, a study with beagle dogs that had been on the pill for three years showed an incidence of breast tissue nodules. Pincus had to establish long term safety, as well as efficacy, of his progesterone contraceptive.

In order to prove the safety of "the pill," human trials had to be conducted. These were initiated on medical students and institutionalized patients in Massachusetts. There was a high incidence of side effects, which led to the Massachusetts trials being abandoned when the women refused to continue taking the contraceptive. Puerto Rico was selected as a trial site in 1954, in part because there was an existing network of 67 birth control clinics servicing low-income women on the island. Trails began there in 1956 and were supervised by Dr. Edris Rice-Wray. Women, once again, experienced severe side effects from "the pill" (Envoid). Rice-Wray wrote Pincus and reported that Envoid "gives one hundred percent protection against pregnancy" but causes "too many side reactions to be acceptable". Pincus disagreed. The trails went on and were expanded to Haiti, despite high attrition rates, due to the large number of women eager to try this form of contraception. In May 1960, the FDA approved Envoid for contraceptive use.

Pincus's successes led to Searle introducing the first widely available oral contraceptive ("the pill"). The social, religious, ethical, and medical ramifications of this discovery are still being felt throughout the world, and his discoveries also led to the burgeoning sciences of steroidal hormone research, sex hormone research, and new forms of oncology. Pincus's work may be some of the most influential science of the twentieth century.

See also: A&E's Biography of the Millennium

References

  • Briggs, Laura (2002). Reproducing Empire: Race, Sex, Science, and U.S. Imperialism in Puerto Rico. Los Angeles: University of California Press. ISBN 0520232585.
  • Tone, Andrea (2001). Devices and Desires. New York: Hill and Wang, A Division of Farrar, Strauss and Giroux. ISBN 080903817X.

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See also: A&E's Biography of the Millennium. Mencius spoke frequently and highly of the well-field system. Pincus's work may be some of the most influential science of the twentieth century. In contrast to the sayings of Confucius which are short and self-contained, the Mencius consists of long dialogues, with extensive prose. The social, religious, ethical, and medical ramifications of this discovery are still being felt throughout the world, and his discoveries also led to the burgeoning sciences of steroidal hormone research, sex hormone research, and new forms of oncology. The Mencius (also spelled Mengzi or Meng-tzu), a book of his conversations with kings of the time, is one of the four books that form the core of orthodox Confucian thinking. Pincus's successes led to Searle introducing the first widely available oral contraceptive ("the pill"). Mencius' interpretation of Confucianism has generally been considered the orthodox version by subsequent Chinese philosophers, especially the Neo-Confucians of the Song dynasty.

In May 1960, the FDA approved Envoid for contraceptive use. Mencius argued that human beings are born with an innate moral sense which society has corrupted, and that the goal of moral cultivation is to return to one's innate morality. The trails went on and were expanded to Haiti, despite high attrition rates, due to the large number of women eager to try this form of contraception. He even argued that it was acceptable for people to overthrow or even kill a ruler who ignored the people's needs and ruled harshly. Pincus disagreed. A follower of Confucianism, Mencius argued for the infinite goodness of the individual, believing that it was society's influence – its lack of a positive cultivating influence – which caused bad character. Rice-Wray wrote Pincus and reported that Envoid "gives one hundred percent protection against pregnancy" but causes "too many side reactions to be acceptable". Disappointed at his failure to effect changes in his contemporary world, he retired from public life.

Women, once again, experienced severe side effects from "the pill" (Envoid). He expressed his filial devotion when he took an absence of three years from his official duties for Qi to mourn his mother's death. Edris Rice-Wray. He served as an official during the Warring States Period (403–221 BCE) in the State of Qi (齊 qì) from 319 to 312 BCE. Trails began there in 1956 and were supervised by Dr. Like Confucius, according to legend, he travelled China for forty years to offer advice to rulers for reform. Puerto Rico was selected as a trial site in 1954, in part because there was an existing network of 67 birth control clinics servicing low-income women on the island. He was an itinerant Chinese philosopher and sage, and one of the principal interpreters of Confucianism.

There was a high incidence of side effects, which led to the Massachusetts trials being abandoned when the women refused to continue taking the contraceptive. Mencius (most accepted dates: 372–289 BCE; other possible dates: 385–BC/302 BCE), also known by his birth name Meng Ke or Ko, was born in the State of Zou (鄒國), now forming the territory of the county-level city of Zoucheng (邹城市), Shandong province, only thirty kilometres (eighteen miles) south of Qufu, Confucius' birthplace. These were initiated on medical students and institutionalized patients in Massachusetts. In order to prove the safety of "the pill," human trials had to be conducted. Pincus had to establish long term safety, as well as efficacy, of his progesterone contraceptive.

However, despite early success in preventing ovulation, and therefore fertilization, a study with beagle dogs that had been on the pill for three years showed an incidence of breast tissue nodules. Pincus, along with Min-Chueh Chang, investigated and established that progesterone would act as an inhibitor to ovulation. In 1953, Margaret Sanger and Katherine McCormick sought out Pincus for a project involving contraception. His experiments involving parthenogenesis produced a rabbit that appeared on the cover of Look magazine in 1937 and led to his dismissal from Harvard University.

Pincus's first breakthrough came early, when he was able to produce in vitro fertilization in rabbits in 1934. He was instrumental in persuading Searle to fund this research, at a time when Pfizer and Parke-Davis were reluctant to fund human trials. Pincus began studying hormonal biology and steroidal hormones early in his career. Gregory Goodwin Pincus (April 9, 1903 - August 22, 1967), American physician, biologist, and researcher, was co-inventor of the contraceptive pill.

ISBN 080903817X. New York: Hill and Wang, A Division of Farrar, Strauss and Giroux. Devices and Desires. Tone, Andrea (2001).

ISBN 0520232585. Los Angeles: University of California Press. Imperialism in Puerto Rico. Reproducing Empire: Race, Sex, Science, and U.S.

Briggs, Laura (2002).