This page will contain blogs about ricin, as they become available.RicinCastor beansThe protein ricin (pronounced rye-sin) is a poison manufactured from the castor bean (Ricinus communis). Its name comes from the seed's resemblance to the tick. Ricin can be extracted from castor beans and is known to have an average lethal dose in humans of 0.2 milligrams (1/5,000th of a gram), though some sources give higher figures [1]. It is considered to be twice as deadly as cobra venom. Toxicity and manufactureRicin is poisonous if inhaled, injected, or ingested, acting as a toxin by the inhibition of protein synthesis. There is no known antidote; only symptomatic and supportive treatment is available. Long term organ damage is likely in survivors. In small doses, such as the typical dose contained in a measure of castor oil, ricin causes digestive tract cramps. Ingested in larger doses, ricin causes severe diarrhea and victims can die of shock. (See abrin). Although the castor bean plant has long been noted for its toxicity, ricin was first isolated and named in 1888 by Hermann Stillmark. Modern feed-making techniques break down the ricin in castor beans by heating at 140 degrees Celsius for 20 minutes, although some studies suggest that residual toxic effects may linger. Although one seed contains enough ricin to kill an adult human, they may pass harmlessly through the digestive system if swallowed whole. [2]. Typically 2.5–20 raw seeds can kill an adult human; 4 a rabbit, 5 a sheep, 6 an ox, 6 a horse, 7 a pig, 11 a dog, but 80 for cocks and ducks.[3] Ricin consists of two distinct protein chains (almost 30kDa each) that are linked to each other by disulfide bond:
Many plants such as barley have the A chain but not the B chain. Since people do not get sick from eating large amounts of such products, ricin A is of extremely low toxicity if and only if the B chain is not present. Ricin is easily purified from castor-oil manufacturing waste. The seed-pulp left over from pressing for castor oil contains on average about 5% by weight of ricin. Since 0.2 mg of purified Ricin constitutes a fatal dose, this is a considerable amount of ricin. As little as one castor bean, about 0.5 grams, may be fatal in a child. In the United states, a person caught manufacturing or possessing ricin may be sentenced up to 30 years in prison. Potential medicinal useRicin may have therapeutic use in the treatment of cancer. Ricin could be linked to a monoclonal antibody to target malignant cells recognized by the antibody. Genetic modification of ricin is believed to be possible to lessen its toxicity to humans, but not to the cancer cells. A promising approach is also to use the non-toxic B subunit as a vehicle for delivering antigens into cells thus greatly increasing their immunogenicity. Use of ricin as an adjuvant has potential implications for developing mucosal vaccines Use as a chemical/biological warfare agentThe United States investigated ricin for its military potential during the First World War. At that time it was being considered for use either as a toxic dust or coated bullets and shrapnel. The dust cloud concept could not be adequately developed, and researchers believed the coated bullet/shrapnel concept was unethical. The War ended before it was weaponized. During the Second World War the United States and Canada undertook studying ricin in cluster bombs. Though there were plans for mass production and several field trials with different bomblet concepts, the end conclusion was that it was no more economical than using phosgene. This conclusion was based on comparison of the final weapons rather than ricin's toxicity (LD50 <30 mg.min.m–3). Ricin was given the military symbol W. The best-known documented use of ricin as an agent of biological warfare was by the Soviet Union's KGB during the Cold War. In 1978, the Bulgarian dissident Georgi Markov was assassinated by Bulgarian secret police who surreptitiously 'shot' him on a London street with a modified umbrella using compressed gas to fire a tiny pellet contaminated with ricin into his leg. He died in hospital a few days later; the pellet was discovered by chance during an autopsy and the poison linked back to the KGB. Earlier, Soviet dissident Aleksandr Solzhenitsyn also suffered (but survived) ricin-like symptoms after a 1971 encounter with KGB agents (D.M. Thomas, Alexander Solzhenitsyn: A Century in His Life, 368-378). Despite ricin's extreme toxicity and utility as an agent of chemical/biological warfare, it is extremely difficult to limit the production of the toxin. Under both the 1972 Biological Weapons Convention and the 1997 Chemical Weapons Convention, ricin is listed as a schedule 1 controlled substance. Despite this, more than 1 million metric tonnes of castor beans are processed each year, and approximately 5% of the total is rendered into a waste containing high concentrations of ricin toxin [4]. In August of 2002, US officials asserted that the Islamic militant group Ansar al-Islam tested ricin, along with other chemical and biological agents, in northern Iraq. To put ricin used as weapon into perspective, it is worth noting that as a biological weapon or chemical weapon, ricin may be considered as not very powerful, if only in comparison with other poisons such as botulinum or anthrax. Hence, a military willing to use biological weapons and having advanced resources would rather use either of the latter instead. Ricin is easy to produce, but is not as practical nor likely to cause as high casualities as other agents. Ricin denatures (ie, the protein changes structure and becomes less dangerous) much more readily than anthrax spores, which may remain lethal for decades. (Jan van Aken, an expert on biological weapons explained in an interview with the German magazine Der Spiegel that he judges it rather reassuring that Al Qaeda experimented with ricin as it suggests their inability to produce botulin or anthrax.) Pure ricin could be dispersed through the air, however it would tend to be oxidized and rendered harmless by ozone, nitrogen oxides, and other pollutants in a matter of hours. Since it acts as an enzyme, catalyzing destruction of ribosomes, even a single oxidation is likely to render the ricin molecule harmless. Presumably it could be sealed inside some sort of dust particle that would dissolve in water, but this would be difficult. The major reason it is dangerous is that there is no specific antidote, and that it is very easy to obtain (the castor bean plant is a common ornamental, and can be grown at home without any special care). Ricin is actually several orders of magnitude less toxic than botulinum or tetanus toxins, but those are more difficult to obtain. Ricin patent"Preparation of Toxic Ricin",patent application. The process for creating ricin is well-known, in part because a patent was granted for it in 1952. The inventors named in US Patent 3,060,165 (granted October 23, 1962) "Preparation of Toxic Ricin", assigned to the U.S. Secretary of the Army, are Harry L. Craig, O.H. Alderks, Alsoph H. Corwin, Sally H. Dieke, and Charlotte Karel. The patent was removed from the United States Patent and Trademark Office (USPTO) database sometime in 2004, but is still available online through international patent databases. Ricin extraction processThe extraction of ricin from castor beans is very similar to the prepartion of soy protein isolates. Modern extraction plants might use membrane filtration to make highly purified ricin isolates Ricin is initially extracted from defatted castor beans by aquous extraction at pH 3.8 to yield a leachate containing solubilized ricin. The leachate is filtered to remove insoluble matter and the crude ricin then precipitated by the addition of a 12% solution of sodium sulfate with a pH of 7.0-8.0. After precipitation, the crude ricin cake is washed with a 16.7% solution of sodium sulfate to remove extranious nitrogenous substances. The precipitated ricin may be reextracted once to further purify it. The final ricin precipitate is dried and then purified by floatation in carbon tetrachloride. An aerosol powder may be prepared by spray drying or air grinding the purified ricin using cold air. Ricin-related arrests in Britain in 2003It was widely reported in the media that traces of ricin were detected by British police in a flat in Wood Green, North London after a raid on a suspected ring of terrorists on 5 January 2003. Media reports stated that a group was suspected of intending to use the poison in an attack on the London Underground. However at the trial of Kamel Bourgass in 2005 it became apparent that within a few days of the raid the leader of the Biological Weapon Identification Group at the Porton Down Defence Science and Technology Laboratory had concluded that ricin was not present at Wood Green [5] [6]. Some acetone, 22 castor beans, and poor recipes for ricin and other poisons copied from the Internet were found. It appears that an individual conducting amateur research on poisons was found in this raid. A little later several arrests were made in France and a bottle of something that tested positive for ricin was found. Further analysis identified the material as ground wheat germ. The analytic confusion was caused by the similarity of many plant proteins to one of the ricin components, which suggests that higher quality (better specificity and sensitivity) analytic tests for ricin are needed. Six more suspects were arrested in Bournemouth in England in connection with the investigation into the alleged ricin incident in London. They were not convicted of any poisons related crime. Three more suspects were arrested in Manchester in England in connection with the investigation of the alleged ricin found in London, following a raid carried out pursuant to an investigation into immigration issues. A Special Branch policeman, DC Stephen Oake, was fatally stabbed during the arrests, and three other officers were also injured, one seriously. On January 20, 2003 Finsbury Park mosque was raided by police, apparently as part of the investigation into the alleged discovery of ricin in Wood Green. A number of men who were apparently living at the mosque were arrested. On February 5, 2003, U.S. Secretary of State Colin Powell presented those arrested as the "UK Poison Cell" of a global terrorist network in making the case for military intervention in Iraq to the UN Security Council [7]. In April 2005 31-year-old Kamel Bourgass was jailed for 17 years after being convicted of conspiracy to commit a public nuisance "by the use of poisons and explosives to cause disruption, fear or injury". He was also jailed for life following a conviction for murdering the Special Branch policeman who went to arrest him. All others accused in connection with the Wood Green flat were acquitted on all counts. Ricin in Washington, D.C.Ricin was detected in the mail at the White House in Washington, D.C. in November of 2003. The letter containing it was intercepted at a mail handling facility off the grounds of the White House, and it never reached its intended destination. The letter contained a fine powdery substance that later tested positive for ricin. Investigators said it was low potency and was not considered a health risk. This information was not made public until February 3, 2004, when preliminary tests showed the presence of ricin in an office mailroom of U.S. Senate Majority Leader Bill Frist's office. There were no signs that anyone who was near the contaminated area developed any medical problems. Several Senate office buildings were closed as a precaution. Ricin in popular cultureRicin was the poison used in the Agatha Christie Tommy and Tuppence whodunnit The House of Lurking Death in a 1929 collection of short stories called Partners in Crime. Ricin was used as the poison of choice of the murderer in the 1962 comedy film Kill or Cure. Ricin was mentioned in the "call me the prankster" comic at toothpaste for dinner The Penn and Teller book How To Play With Your Food (ISBN 0679743111) includes a "gimmicks envelope" of small objects related to the tricks inside the book. One of these is a sticker reading "With all-natural ricin!". The book explains that ricin is a poison. This page about ricin includes information from a Wikipedia article. Additional articles about ricin News stories about ricin External links for ricin Videos for ricin Wikis about ricin Discussion Groups about ricin Blogs about ricin Images of ricin |
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The book explains that ricin is a poison. The Simpsons has run for three seasons of shorts and seventeen full seasons since its conception. One of these is a sticker reading "With all-natural ricin!". These include:. The Penn and Teller book How To Play With Your Food (ISBN 0679743111) includes a "gimmicks envelope" of small objects related to the tricks inside the book. There are many recurring gags on the Simpsons, many of which have been retired during the run of the series or implemented later on. Ricin was mentioned in the "call me the prankster" comic at toothpaste for dinner. The characters were also given typical Arabic names (such as Omar, Mona and Abar for Homer, Marge and Bart respectively) as part of the retooling, while voices were provided by leading actors including Egyptian film star Mohamed Heneidi as "Omar.". Ricin was used as the poison of choice of the murderer in the 1962 comedy film Kill or Cure. For instance, Homer drinks soda (not beer) and eats beef sausages. Ricin was the poison used in the Agatha Christie Tommy and Tuppence whodunnit The House of Lurking Death in a 1929 collection of short stories called Partners in Crime. The program finally made an official debut in Arabic-speaking markets in September of 2005, under a title that transliterates as "El Shempshoon" or "Al-Shamshoon" (In Arabic, سيمبسونس ) In addition to being dubbed in Arabic (with subtitles provided for shots including written English, such as the chalkboards), references to alcohol (Duff Beer & Moe's Tavern), pork (bacon & hot dogs), and numerous other themes have been deleted or significantly modified. Several Senate office buildings were closed as a precaution. News website Corona posted a popular April Fool's Day hoax describing fictional plans for a live action movie. There were no signs that anyone who was near the contaminated area developed any medical problems. IMDb has also created a page for The Simpsons movie, and claims a release date of November 2008, while Yahoo! Movies reports that The Simpsons Movie will be released in 2007. Senate Majority Leader Bill Frist's office. It is speculated that there will also be guest stars appearing in large roles or cameos. This information was not made public until February 3, 2004, when preliminary tests showed the presence of ricin in an office mailroom of U.S. Just like the series, the movie will be animated (Matt Groening recently turned down a proposal to make a live action film based on the characters, as this would likely ruin the franchise and anger fans) and will star the six main voice actors: Dan Castellaneta, Julie Kavner, Nancy Cartwright, Yeardley Smith, Hank Azaria, Harry Shearer, and most likely Marcia Wallace, Maggie Roswell, Pamela Hayden, and Tress MacNeille. Investigators said it was low potency and was not considered a health risk. This was confirmed by 20th Century Fox on June 6, 2005. The letter contained a fine powdery substance that later tested positive for ricin. With the series being renewed for a twentieth season, an estimated premiere date for The Simpsons Movie was set for the summer of 2008. The letter containing it was intercepted at a mail handling facility off the grounds of the White House, and it never reached its intended destination. In that year, producers announced a theatrical movie is in the very early stages of development, and that it will not be released until after the series ends. in November of 2003. Rumors were circulated on the Internet about a movie already being in development, but it was not until 2004 that any were confirmed. Ricin was detected in the mail at the White House in Washington, D.C. The episode "Kamp Krusty" was originally going to be a movie, but became a regular episode after difficulties were encountered in trying to expand the script to feature-length. All others accused in connection with the Wood Green flat were acquitted on all counts. Talk about a possible feature-length Simpsons movie has been going on since the early days of the series. He was also jailed for life following a conviction for murdering the Special Branch policeman who went to arrest him. A number of men who were apparently living at the mosque were arrested. However, no news or any development has been announced since then. On January 20, 2003 Finsbury Park mosque was raided by police, apparently as part of the investigation into the alleged discovery of ricin in Wood Green. Vivendi Universal Games, the publisher of recent Simpsons games, announced shortly after the release of The Simpsons: Hit and Run that there was a sequel in the works. A Special Branch policeman, DC Stephen Oake, was fatally stabbed during the arrests, and three other officers were also injured, one seriously. There are at least two Simpsons pinball games as well, one released after the first season, and the other still available. Three more suspects were arrested in Manchester in England in connection with the investigation of the alleged ricin found in London, following a raid carried out pursuant to an investigation into immigration issues. The most well-regarded Simpsons game is The Simpsons: Hit and Run, which incorporated the free-roaming environment made popular by the Grand Theft Auto series as well as the involvement of the Simpsons writing staff, creating an authentic, interactive Springfield that was praised by critics and the fanbase alike. They were not convicted of any poisons related crime. However, the recent generation has been better received by the general public, starting with The Simpsons Road Rage; which, while not considered a good game, was certainly an improvement. Six more suspects were arrested in Bournemouth in England in connection with the investigation into the alleged ricin incident in London. However, other than the classic arcade game, most Simpsons video games were despised by critics for their poor worksmanship and actual functionality. The analytic confusion was caused by the similarity of many plant proteins to one of the ricin components, which suggests that higher quality (better specificity and sensitivity) analytic tests for ricin are needed. Various games have been made, including The Simpsons: Hit and Run, The Simpsons Road Rage, and Krusty's Super Fun House. Further analysis identified the material as ground wheat germ. It was, at the time, one of the most successful arcade games ever. A little later several arrests were made in France and a bottle of something that tested positive for ricin was found. The first game was The Simpsons (arcade game), published by Konami. It appears that an individual conducting amateur research on poisons was found in this raid. Video games starring The Simpsons have been made since 1991. Some acetone, 22 castor beans, and poor recipes for ricin and other poisons copied from the Internet were found. In particular, these DVDs have been released in North America (Region 1), Europe (Region 2) and Australia/New Zealand/Latin America (Region 4). However at the trial of Kamel Bourgass in 2005 it became apparent that within a few days of the raid the leader of the Biological Weapon Identification Group at the Porton Down Defence Science and Technology Laboratory had concluded that ricin was not present at Wood Green [5] [6]. The seven DVD volumes rank as the best-selling television DVD series of all time. Media reports stated that a group was suspected of intending to use the poison in an attack on the London Underground. When the first season DVD was released in 2001, it quickly became the best-selling television DVD in history (although it would later be overtaken by the first season of Chappelle's Show) [4]. It was widely reported in the media that traces of ricin were detected by British police in a flat in Wood Green, North London after a raid on a suspected ring of terrorists on 5 January 2003. Many episodes of the show have been released on DVD and VHS over the years. An aerosol powder may be prepared by spray drying or air grinding the purified ricin using cold air. the Space Mutants) are considered minor video game classics in their own right. The final ricin precipitate is dried and then purified by floatation in carbon tetrachloride. While there have always been flops, the majority of Simpsons games did very well commercially and some (such as The Simpsons: The Arcade Game and Bart vs. The precipitated ricin may be reextracted once to further purify it. With the incredible popularity of The Simpsons, especially amongst children, it was only natural for the video game industry to turn to the characters and world of Springfield. After precipitation, the crude ricin cake is washed with a 16.7% solution of sodium sulfate to remove extranious nitrogenous substances. Songs in the Key of Springfield and Go Simpsonic with The Simpsons are CD collections of original music featured in the TV series. The leachate is filtered to remove insoluble matter and the crude ricin then precipitated by the addition of a 12% solution of sodium sulfate with a pH of 7.0-8.0. The Simpsons Sing the Blues and The Yellow Album contained cover versions of songs, as well as some originals (including "Do The Bartman"). Ricin is initially extracted from defatted castor beans by aquous extraction at pH 3.8 to yield a leachate containing solubilized ricin. Perhaps the best known song is "Do The Bartman", which was released as a single and became an international success. Modern extraction plants might use membrane filtration to make highly purified ricin isolates. Music is prominently featured in The Simpsons, with virtually all members of the cast breaking into song at least once during the course of the series. The extraction of ricin from castor beans is very similar to the prepartion of soy protein isolates. The comics have also been collected in book form; many other Simpsons books such as episode guides have also been published. The patent was removed from the United States Patent and Trademark Office (USPTO) database sometime in 2004, but is still available online through international patent databases. The Simpsons, Futurama, and Bart Simpson comics are also reprinted in the UK, under the same titles, with various stories from the other Bongo series reprinted in the main Simpsons comic. Dieke, and Charlotte Karel. Numerous different Simpsons-related comic book series have been published by Bongo Comics since 1993. Corwin, Sally H. Simpsons-related publications include:. Alderks, Alsoph H. Serious academic work has been done on the show. Craig, O.H. Pastor Richards asks an opponent the question: "If you don't like the United States, son, why don't you move to Russia?" this is similar to Homer's comment in Treehouse of Horror II, where he states: "Hey! If you don't like it, go to Russia!". Secretary of the Army, are Harry L. Another reference from Vice City to the Simpsons is also featured on VCPR radio. The inventors named in US Patent 3,060,165 (granted October 23, 1962) "Preparation of Toxic Ricin", assigned to the U.S. A reference to this scene can be heard on VCPR radio in Grand Theft Auto: Vice City: "I, for one, welcome our new Russian masters". The process for creating ricin is well-known, in part because a patent was granted for it in 1952. In various internet communities, the popular meme "I, for one, welcome our new <Insert topic here> overlords!" stems from a quote of Kent Brockman from the episode "Deep Space Homer". Ricin is actually several orders of magnitude less toxic than botulinum or tetanus toxins, but those are more difficult to obtain. Groundskeeper Willie's description of the French as "cheese-eating surrender monkeys" was used by conservative National Review columnist Jonah Goldberg, a fan of the show, in 2003, after France's opposition to the proposed invasion of Iraq, and quickly spread to other journalists. The major reason it is dangerous is that there is no specific antidote, and that it is very easy to obtain (the castor bean plant is a common ornamental, and can be grown at home without any special care). The show's creators also take pride in having passed on schoolyard rhymes to a new generation of children who otherwise may not have heard them. Presumably it could be sealed inside some sort of dust particle that would dissolve in water, but this would be difficult. Since the debut of the show, the term "Smithers" has become a common eponym for a spineless underling. Since it acts as an enzyme, catalyzing destruction of ribosomes, even a single oxidation is likely to render the ricin molecule harmless. The character Waylon Smithers is another such example. Pure ricin could be dispersed through the air, however it would tend to be oxidized and rendered harmless by ozone, nitrogen oxides, and other pollutants in a matter of hours. Character Barney Gumble, whose name is in reference to The Flintstones' Barney Rubble, is also famous for delivering long belches frequently. (Jan van Aken, an expert on biological weapons explained in an interview with the German magazine Der Spiegel that he judges it rather reassuring that Al Qaeda experimented with ricin as it suggests their inability to produce botulin or anthrax.). "Woohoo" subsequently became the catch phrase of Melissa Joan Hart's portrayal of Sabrina in Sabrina The Teenage Witch. Ricin denatures (ie, the protein changes structure and becomes less dangerous) much more readily than anthrax spores, which may remain lethal for decades. Other Simpsons expressions that have entered into popular use include the word "excellent" — drawn out as a sinister and breathy "eeeexcelllent…" in the style of Montgomery Burns — Homer's triumphant "Woohoo!" and Nelson Muntz's mocking "HA-ha!". Ricin is easy to produce, but is not as practical nor likely to cause as high casualities as other agents. He was told by the show's director to shorten the noise, leading to the annoyed grunt we know today. Hence, a military willing to use biological weapons and having advanced resources would rather use either of the latter instead. Dan Castellaneta has explained that he borrowed the phrase from an actor in early Laurel and Hardy comedies, but that he originally pronounced it much more stretched-out and whiny. To put ricin used as weapon into perspective, it is worth noting that as a biological weapon or chemical weapon, ricin may be considered as not very powerful, if only in comparison with other poisons such as botulinum or anthrax. A much earlier use of the same expression, often similarly used to denote thwarted expectation, was established in the long-running BBC (UK) radio series The Archers, where it was used, almost as a catch-phrase, by the character 'Walter Gabriel' (voiced by actor Chris Gittings). In August of 2002, US officials asserted that the Islamic militant group Ansar al-Islam tested ricin, along with other chemical and biological agents, in northern Iraq. "D'oh" is the accepted spelling, and is certainly the most common; the closed captions for the program (at least in the U.S.), however, spell it "D-OHH". Despite this, more than 1 million metric tonnes of castor beans are processed each year, and approximately 5% of the total is rendered into a waste containing high concentrations of ricin toxin [4]. So ubiquitous is the catchphrase that it is now listed in the Oxford English Dictionary, but without the apostrophe. Under both the 1972 Biological Weapons Convention and the 1997 Chemical Weapons Convention, ricin is listed as a schedule 1 controlled substance. A number of neologisms originated on The Simpsons have become a part of the universal lexicon, the most famous of which is Homer's saying: "D'oh!", which is referred to in scripts, as well as four episode names, as "annoyed grunt". Despite ricin's extreme toxicity and utility as an agent of chemical/biological warfare, it is extremely difficult to limit the production of the toxin. For instance, the character of Homer Simpson is so universally renowned that any use of the name is instantly recognized almost anywhere on the planet as a reference to the show and asserted as relating to immense stupidity, one of the character's key trademarks. Thomas, Alexander Solzhenitsyn: A Century in His Life, 368-378). More than any other series in history, The Simpsons has become so embedded in the fiber of Western culture that many of its characters, concepts and catchphrases have become common knowledge in modern society. Earlier, Soviet dissident Aleksandr Solzhenitsyn also suffered (but survived) ricin-like symptoms after a 1971 encounter with KGB agents (D.M. The shift was mainly from an esoteric style to more broad humor, which has helped widen its audience yet alienate others. He died in hospital a few days later; the pellet was discovered by chance during an autopsy and the poison linked back to the KGB. Particularly physical and visual humor often taking the place of complex intellectual dialog. In 1978, the Bulgarian dissident Georgi Markov was assassinated by Bulgarian secret police who surreptitiously 'shot' him on a London street with a modified umbrella using compressed gas to fire a tiny pellet contaminated with ricin into his leg. In order to fit this new style, character changes also came to pass, trading depth for somewhat of a one-dimensionalism to better blend into the types of zany and outlandish situations that stories were now introducing. The best-known documented use of ricin as an agent of biological warfare was by the Soviet Union's KGB during the Cold War. While wit and satire were still key in stories, a shift from realism to more fantasy-type situations occurred. Ricin was given the military symbol W. As seasons progressed, new producers and teams of writers took the helm, gradually introducing new visions and style to the show. This conclusion was based on comparison of the final weapons rather than ricin's toxicity (LD50 <30 mg.min.m–3). Fair targets included family, work, religion, school and society in general, using subtle wit and well made observations about the seeming absurdity of it all--all delivered compellingly through written dialog and stories. Though there were plans for mass production and several field trials with different bomblet concepts, the end conclusion was that it was no more economical than using phosgene. While it was in animated form, it did not rely on the medium for its comedic basis, but rather focusing on realistic situations and events, playing off the absurdity of what society consider the norm and intelligently poking fun at that. During the Second World War the United States and Canada undertook studying ricin in cluster bombs. During its initial run, and well into its first several seasons, The Simpsons had been widely heralded as a unique form of television satire that took an intellectual look and examination of common everyday life. The War ended before it was weaponized. By the end of its 16th season, the show had accumulated 356 episodes (see list). The dust cloud concept could not be adequately developed, and researchers believed the coated bullet/shrapnel concept was unethical. "The Simpsons" is one of the longest running TV shows ever created. At that time it was being considered for use either as a toxic dust or coated bullets and shrapnel. The Simpsons has been widely distributed internationally; for a list of distributors, see List of TV channels that air The Simpsons. The United States investigated ricin for its military potential during the First World War. Tennis the Menace, however, being already completed, was broadcast this way. Use of ricin as an adjuvant has potential implications for developing mucosal vaccines. The first episode to experiment with digital coloring was "Radioactive Man" in 1995, and again during season 12 with the episode "Tennis the Menace", but after seeing the results, Gracie Films decided to hold off for two more seasons. A promising approach is also to use the non-toxic B subunit as a vehicle for delivering antigens into cells thus greatly increasing their immunogenicity. After season 13, production was switched from traditional cel animation to digital ink and paint. Genetic modification of ricin is believed to be possible to lessen its toxicity to humans, but not to the cancer cells. The last episode to be animated by Klasky Csupo was "Kamp Krusty", in production order. Ricin could be linked to a monoclonal antibody to target malignant cells recognized by the antibody. During season four, Gracie Films made a decision to switch domestic production to Film Roman, which continues to animate the show to this day. Ricin may have therapeutic use in the treatment of cancer. Throughout the years, different overseas studios have animated different episodes, even episodes within the same season. In the United states, a person caught manufacturing or possessing ricin may be sentenced up to 30 years in prison. While character and background layout is done by the domestic studio, inbetweening, coloring and filming is done by the overseas studios. As little as one castor bean, about 0.5 grams, may be fatal in a child. Klasky Csupo was also the animation studio during the first three seasons of the half-hour length series, however, due to the increased workload, production was now being subcontracted to overseas studios, usually in South Korea. Since 0.2 mg of purified Ricin constitutes a fatal dose, this is a considerable amount of ricin. Throughout the run of the animated shorts on The Tracey Ullman Show, the animation was solely produced domestically at Klasky Csupo. The seed-pulp left over from pressing for castor oil contains on average about 5% by weight of ricin. The Simpsons has been animated by many different studios over the past 18 years, both domestic and overseas. Ricin is easily purified from castor-oil manufacturing waste. Toonzone Entertainment—2 episodes. Since people do not get sick from eating large amounts of such products, ricin A is of extremely low toxicity if and only if the B chain is not present.. Animation, Inc.—2 episodes. Many plants such as barley have the A chain but not the B chain. U.S. Ricin consists of two distinct protein chains (almost 30kDa each) that are linked to each other by disulfide bond:. Rough Draft Studios—115 episodes. Typically 2.5–20 raw seeds can kill an adult human; 4 a rabbit, 5 a sheep, 6 an ox, 6 a horse, 7 a pig, 11 a dog, but 80 for cocks and ducks.[3]. Anivision—55 episodes. [2]. AKOM—195 episodes. Although one seed contains enough ricin to kill an adult human, they may pass harmlessly through the digestive system if swallowed whole. Overseas animation studios involved:. Modern feed-making techniques break down the ricin in castor beans by heating at 140 degrees Celsius for 20 minutes, although some studies suggest that residual toxic effects may linger. In 2005 English comedian Ricky Gervais was asked to write an episode, which should be airing in 2006. Although the castor bean plant has long been noted for its toxicity, ricin was first isolated and named in 1888 by Hermann Stillmark. The character Professor John Frink was named for a friend of Al Jean's, John Frink, who later became a writer/producer of the show. (See abrin). Ian was the basis for the Very Tall Man character in the Season 7 episode 22 Short Films About Springfield. Ingested in larger doses, ricin causes severe diarrhea and victims can die of shock. Ian Maxtone-Graham has been a prominent writer for The Simpsons since the eighth season. In small doses, such as the typical dose contained in a measure of castor oil, ricin causes digestive tract cramps. the Monorail" (9F10), "Homer Goes to College" (1F02) and part of "Treehouse of Horror IV" (1F04). Long term organ damage is likely in survivors. He wrote "New Kid on the Block" (9F06), "Marge vs. There is no known antidote; only symptomatic and supportive treatment is available. Current late-night talk show host Conan O'Brien was a writer during the fourth and fifth season. Ricin is poisonous if inhaled, injected, or ingested, acting as a toxin by the inhibition of protein synthesis. George Meyer became a writer for the show in 1989, and in 2000 was called the "the funniest man behind the funniest show on TV" by The New Yorker.[3]. . When the state of California passed an anti-smoking law, Swartzwelder bought a diner booth and installed it in his house, allowing him to smoke and write in peace. It is considered to be twice as deadly as cobra venom. According to the DVD commentaries, he used to write episodes while sitting at a booth in his favorite restaurant "drinking copious amounts of coffee and smoking endless cigarettes" (Matt Groening). Ricin can be extracted from castor beans and is known to have an average lethal dose in humans of 0.2 milligrams (1/5,000th of a gram), though some sources give higher figures [1]. John Swartzwelder is the most prolific writer on the Simpsons' staff, personally writing over 50 episodes (more than any other Simpsons writer). Its name comes from the seed's resemblance to the tick. Guest stars had performed as well. The protein ricin (pronounced rye-sin) is a poison manufactured from the castor bean (Ricinus communis). Julius Hibbert, and many more. Ricin B is important in assisting ricin A's entry into a cell by binding with a cell surface component. Burns, Smithers, Principal Seymour Skinner, Otto, Ned Flanders, Kent Brockman, Reverend Lovejoy, Dr. Ricin A is toxic to the cell by interfering with Ribosomes, responsible for protein synthesis. Harry Shearer performs perhaps the largest array of characters, including Mr. Hank Azaria voices Moe, Chief Wiggum, and Apu, as well as other miscellaneous characters. Nancy Cartwright, anomalously, performs the voice of Bart Simpson and other children from the school that he attends. Dan Castellaneta performs the voices of Homer Simpson, his dad, Abraham Simpson, and Krusty the Klown, among others, while Julie Kavner performs the voices of Marge Simpson and her sisters, mother, and (in one episode) her aunt. Yeardley Smith, voice actress of Lisa Simpson, and Marcia Wallace, voice actress of Edna Krabappel, are the only cast members who only do one voice, though both have on occasion voiced one-shot characters. All episodes (with the exception of one) list only the voice actors (not the characters they voice) in keeping with the mystique of having the audience not associate any one character with an actor — this is to discourage the audience from easily identifying exactly which voice actor did what. Some consider its parody of the prequel Star Wars trilogy in the episode Co-Dependent's Day being very harsh considering the show's own "downfall." These attacks have been countered by other fans stating that the show was always more or less mainstream, and nonsensical personality changes and the structural changes were done in a spirit of creative experimentation, and has not damaged the show. Since as early as Season 4, the show has drawn criticism from some fans for straying too far from its comedic structure, for becoming too "mainstream," and changing character personalities without explanation. [2]. The universally reported claim that this dispute was in fact a full-blown strike is denied by Harry Shearer. On May 2, 2004, the actors resolved their dispute with Fox after having their demands met. They asked for $360,000 per episode, or $8 million for a 22-episode season. [1] As the revenue generated by the show continued to increase through syndication and DVD sales, six actors (playing over 50 characters) — Dan Castellaneta, Julie Kavner, Nancy Cartwright, Yeardley Smith, Hank Azaria, and Harry Shearer — stopped showing up for script readings in April 2004 after weeks of unsuccessful negotiations with Fox. The actors were supported in their action by series creator Matt Groening. In 1998, the voice actors stopped working, forcing 20th Century Fox TV to increase their salary from $30,000 per episode to $125,000. The voice actors have been involved in much-publicized pay disputes with Fox on more than one occasion. On January 14, 2000 the Simpsons were awarded a star on the Hollywood Walk of Fame. The Simpsons has won dozens of awards since it debuted as a series, including 21 Emmy Awards, 22 Annie Awards, a Peabody and numerous others (see the list of awards won by The Simpsons for more details). Over the years, virtually every Simpsons character has appeared on a magazine cover, ranging from TIME to Christianity Today and even Airliners. Since the series originated as part of The Tracey Ullman Show, it is also considered the longest running and most successful spinoff of all time. He was the only fictional character on the list. In that same issue, Bart Simpson was named to the Time 100, the publication's list of the century's 100 most influential people. In its 1998 issue celebrating the greatest achievements in arts and entertainment of the 20th Century, TIME magazine named The Simpsons the century's best television series. Some take the view that The Adventures of Ozzie and Harriet should continue to be counted as the longest-running sitcom as The Simpsons is animated, not live-action, although this view is declining as more authorities unambiguously credit The Simpsons as television's longest-running sitcom. In 2004, the series was renewed through its 19th season. In January 2003, it was announced that the show had been renewed by Fox through 2005 — meaning it has replaced The Adventures of Ozzie and Harriet (1952 to 1966) as longest-running sitcom (animated or live action) ever in the United States. In 2004 it surpassed Scooby Doo in number of episodes. On February 9, 1997 The Simpsons surpassed The Flintstones as the longest-running prime time animated series in America, however it has not yet beaten several Japanese anime series such as Sazae-san (which has been running since 1969) and Doraemon (running since 1979). The creator Matt Groening and some of writers didn't go for the plane's first trip as they feared it would crash, and they would die with the plane. In 1995, Western Pacific Airlines repainted a Boeing 737 jet with Simpsons characters to promote the series. The writers have shown a love for cameo appearances by celebrities and extended pastiches of contemporary and classic movies, as well as subtle visual jokes. Bush said that America needed to be closer to The Waltons than to The Simpsons, causing Bart to say they were a lot like the Waltons, since they were both praying for an end to the Depression. In another address, Mr. The Simpsons Complete Fourth Season DVD set includes a special feature that presents an exchange of letters between the First Lady and show staff. Bush were both portrayed by voice actors. and Mrs. Mr. Wilson). Six years later, an episode had George and Barbara Bush move to Springfield and leave after George gets involved in a feud with the Simpson family (in a style reminiscent of Dennis the Menace and Mr. In September 1990, Barbara Bush said in an interview for People magazine that The Simpsons was the dumbest thing she had ever seen. How old is this thing?". Bart reads his, quoting "Underachiever and proud of it.. and proud of it." The T-shirt is also quoted in the later episode Skinner's Sense of Snow in a student riot, where children find their permanent record books. In this episode, the school counselor quotes the controversial T-shirt by stating, "He is an underachiever.. The outcry against Bart was reflected in the second season opener, featuring an episode called Bart Gets an F where Bart's school wants to make him repeat the fourth grade. When a Simpsons T-shirt was marketed featuring Bart and the logo "Underachiever ('And proud of it, man!')", Simpsons T-shirts and other merchandise were banned from public schools in several areas of the United States. Parents' groups and conservative spokespersons felt that a cartoon character like Bart Simpson provided a poor role model for children. It also sparked controversy, as Bart Simpson was portrayed as a rebellious troublemaker who caused trouble and got away with it. The Simpsons was the first true TV series hit for the FOX Network; it was the first Fox show to appear in the top twenty highest-rated shows of the time. The first full length episode shown was "Simpsons Roasting on an Open Fire", however the intended first episode was "Some Enchanted Evening", but when "Some Enchanted Evening" was completed it was rejected due to poor animation, so Fox aired "Simpsons Roasting on an Open Fire" first. The Simpsons was converted, by a team of production companies that included what is now the Klasky Csupo animation house, into a series for the FOX Network in 1989 and has run as a weekly show on that network ever since. The shorts were aired by the BBC in the UK the first time the shows were broadcast, but not subsequently, though some of them, including "Good Night", were included in a Simpsons anniversary episode. Matt Groening admits the reason that they were so crudely drawn in the beginning was because he could not draw well and the animators did nothing more than just trace over his drawings. The Simpson family first appeared in animated form as shorts on The Tracey Ullman Show, with the first short "Good Night" airing on April 19, 1987. In fact, the highest rated episode featuring celebrity guest voices was New Kids on the Blecch, shown during the 12th season, in which pop stars N*Sync supplied their voices to give helpful advice and dance moves to Bart's boy band "The Party Posse". seasons 7 to 13) or as fictional characters (mainly during the early and later seasons). Many episodes feature celebrity guests contributing their voices to the show, as either themselves (especially during the middle of the Simpsons' years, i.e. Other Treehouse segment name parodies include "Citizen Kang", "The Nightmare on Evergreen Terrace", "The Thing and I", "House of Whacks", and "Reaper Madness". Another recent episode featured a CGI trailer for a comedy about humanoid playing cards. This was one of the few times The Simpsons have strayed from their traditional 2D animation, along with a live action cameo by Regis and Kathie Lee in "Treehouse of Horror IX", a couple of claymation scenes in "'Tis The Fifteenth Season" featuring The California Prunes and Jimmy Stewart, and a live action couch gag consisting of a sketchbook being flipped by a hand to make the characters run towards the couch and sit down. This segment from the Halloween episode was also used as a segment of a film shown in the IMAX 3D film Cyberworld. In a section of "Treehouse of Horror VI" called "Homer³", Homer and Bart go into a three-dimensional world, which Homer likens to Tron, created by Pacific Data Images, a computer animation company. Another mainstay of the Halloween shows is the appearance of the two space aliens Kang and Kodos, introduced in the second segment of the first "Treehouse of Horror". The names have changed in subsequent seasons. This also became a tradition, and has been done in every Halloween episode except I, XII, and XIII. In "Treehouse of Horror II" the writers decided to give the cast and crew of the show scary names in the opening and closing credits (like "Mad Matt Groening" and "James Hell Brooks"). For several years the characters broke the fourth wall and introduced their pieces directly to the audience. In later years the series dropped the framing device of characters telling stories, but kept the Treehouse title. The yearly Halloween special was named "Treehouse of Horror" because the original special depicted the Simpson children in their treehouse telling scary stories to one another. In addition to parodying many classic horror and science fiction films such as The Shining, these Halloween segments frequently spoof episodes of The Twilight Zone such as "Nightmare at 20,000 Feet", "To Serve Man", "Living Doll", "It's a Good Life" and "Little Girl Lost". Regular Simpsons characters play humorous special roles, occasionally being killed in gruesome ways by zombies, monsters, or even each other. These pieces usually involve the family in some horror, science fiction, or supernatural setting; they always take place outside the normal continuity of the show (and are therefore considered to be non-canon), and completely abandon any pretence of being realistic. An annual tradition is a special Halloween episode consisting of three separate, self-contained pieces. Marge Simpson finds the theme tune annoying (Episode 1F11 - "Bart gets famous".). The current arrangement, which dates back to the third season, is orchestrated by Alf Clausen. The series' distinctive theme tune was composed by musician Danny Elfman. The first season opening sequence featured a number of differences from the later seasons, including a scene in which Bart snatched a bus stop sign, forcing several dazed Springfieldians to chase the bus (replaced from the second season by a sequence showing Bart weaving his skateboard between a group of characters), and a shot of Lisa riding her bike on the way home (changed to a camera whip pan across a crowd of characters towards the Simpsons' house). The chalkboard gag lasted several seasons before it was cut to save time; however, it was reintroduced for the premier episode of the 17th season with a self- and education-jeering "Does any kid still do this anymore?". Most couch gags last only about five seconds, but the longest one on record lasted 46 seconds. The "couch gag" sequence is frequently used to help show staff make the show longer or shorter, depending on the length of the episode itself. During three episodes, the opening sequence were parodied; once as "The Thompsons" where the Simpsons enter a witness protection program, once with an overweight Bart, where he cracks the pavement as he leaves the school, runs over pedestrians on the sidewalk, gets hit by Marge's car and crushes the roof of Homer's car, and once as "The Hurricane". In the syndicated version, part or all of the opening sequence is usually cut in order to include more commercials in the show's allotted timeslot. For each episode, the sequence includes a number of variations:. Upon entering, they all speed towards the family room couch where, in comedic parallel with the audience, they settle to watch their "must-see" TV show. The members of the family weave dangerously through traffic and in between fellow (and, from the second season onward, familiar) Springfield denizens, all miraculously reaching home at the exact same time. Burns (seen putting his watch to his ear, then shaking it to get it to work) and Smithers in the background (second season onwards); Marge and Maggie are shown checking out at the supermarket with Maggie traveling across the scanner, ringing up at $847.63, the then-monthly cost of raising a baby (although a 'trivia question' shown as a wraparound for commercials during the episode "The Simpsons 138th Episode Spectacular" claims that the register says "NRA4EVER" ("National Rifle Association Forever"), ironically and comedically portraying the non-aligned writers of the show as gun-crazed right-wingers); the sequence then introduces Lisa (who leaves a band rehearsal, usually playing a different saxophone solo); the family is then shown on their way to their house at 742 Evergreen Terrace (the address varied in the beginning, but the writers now use 742 Evergreen Terrace exclusively). Almost every episode opens with a title shot coming through the cumulus clouds and into the school where Bart is writing lines on the class chalkboard, presumably set as a punishment by one of his teachers for some mischievous deed or wayward comment; Homer is shown leaving the power plant, with Mr. The Simpsons opening sequence is one of the show's most memorable hallmarks. Examples of these stock scenes include:. There are several types of scenes that recur often and have become conventions of the show's storytelling style. Recurring themes in episodes include:. However the plots have never been particularly predictable or constant and tend to be very character-driven. The plots of many episodes focus on the adventures of one particular family member, frequently Homer. However, this has nothing to do with the rest of the episode other than serving as a location from which the family drives before reaching the building site. In the first few scenes, Homer believes he has won a motor boat in a competition, but when he attempts to claim the prize, it emerges he is a victim of a police plot to catch criminals - in Homer's case, for 235 unpaid parking tickets. One example of this is the episode "Lisa the Skeptic" in which Lisa discovers a fake 'angel' fossil later revealed to be a tool for advertising the opening of a new mall. It can be said that the first few minutes of most Simpsons episodes have little to do with the rest of the plot. For example, the description of the 2003 episode "Dude, Where's My Ranch?" offered to Shaw Cable subscribers reads: "After David Byrne turns Homer's anti-(Ned) Flanders song into a monster hit, the family vacations at a dude ranch, where Lisa falls in love.". Episode plots rarely follow any sort of linear course, often taking several digressions to move story lines in unexpected directions, often termed plot drift. Each episode presents some sort of change in that situation, its consequences, and almost always how things get back to normal. A standard "template" Springfield situation, in terms of characters and events, has emerged over the years. Fox News has been portrayed as extremely biased towards conservatives. In fact, ridiculing Fox has become a running joke, of sorts. Even Rupert Murdoch—whose corporate empire includes The Simpsons' broadcast network, Fox—has been gently spoofed in a couple of episodes. Many wealthy characters are members of the Republican Party, which meets in a dark castle. Kent Brockman is a self-important, spoiled TV news anchorman with little regard for journalistic ethics. He will endorse any product for a price. Krusty the Klown has an enthusiastic following among Springfield's kids, but offstage he is a jaded, cynical hack, in poor health from a long history of overindulgence, gambling and substance abuse. The show also routinely mocks and satirizes show business conventions and personalities. Furthermore, Police Sergeant Lou is constantly lecturing Chief Wiggum on his inept law enforcement practices, and even Homer's co-worker Carl, in addition to possessing a Master's degree in Nuclear Engineering, occasionally lambastes Homer's stupidity. Nick Riviera. Hibbert, despite a tendency to laugh at the most inappropriate times, is arguably among the least dysfunctional characters in the series, and is certainly more professionally qualified for medical practice than Dr. For instance, Dr. Some people interpret this as a satire of Hollywood and TV's portrayal of exaggerated 'reverse stereotypes' in which the computer genius is always a black actor. Race relations are also the subject of satire in the show, as the handful of African American characters are almost always portrayed as being more intelligent and rational than their "Yellow" counterparts. As compared with the Simpsons family, the Flanders family is relatively well-off and less dysfunctional, reflecting certain theories expressed by sociologist Max Weber in his seminal work, The Protestant Ethic and the Spirit of Capitalism. In several episodes, God actually intervenes to protect the Flanders family, invoking such Protestant concepts as Predestination. Social conservatives and some evangelical Christians have also pointed to the positive role model of devout Christian Ned Flanders, whose fretfulness is occasionally ridiculed but whose decency never wavers despite constant provocation from Homer (except that time that he had extra-marital sex, or married a cocktail waitress in Las Vegas). Nevertheless, these affairs never occur, and by the end of every episode, Homer and Marge's marriage is strongly affirmed. The show has toyed with the possibility of extramarital affairs, such as when Homer falls for a female nuclear technician who shares his love of donuts, or when Marge's ex-boyfriend Artie Ziff tries to rekindle their old romance. One of the main explanations of this shift is that the Simpsons portrays a traditional nuclear family among a lineup of television sitcoms that now portray less traditional families. During the more recent years of Simpsons production, some social conservatives have come to embrace the show. Nearly every authority figure in the show is portrayed unflatteringly:. This negative reaction was most pronounced during the early seasons of the show. This probably explains the often strong negative reaction to the show from social conservatives. Authority, especially in undeserving hands, is a constant target of the show's often sharp satire. This allows for far more flexibility in plot development than in a typical live-action sitcom constrained by physical limitations and logistics. The cost of having an episode of The Simpsons take place in the mountains, Europe, the city park, or a cruise ship on the ocean (all of which simply use drawn and painted backgrounds) is hardly more than placing the family in the more conventional sitcom settings of a living room, a kitchen, and perhaps one or two related settings. Animation scholars and fans have noted that the series uses the medium of animation to its advantage, allowing the show to take place in many settings and feature a far greater cast of characters than a live-action sitcom. This has not been confirmed officially. According to David Silverman, writer for the series, Springfield is in North Tacoma. Many monuments can be seen all at once, including the Gateway Arch in Missouri and the Needle in Washington. When she climbs up, there is a large panoramic view of what is supposedly Springfield. To do so, she climbs up to prevent the team from cutting it down. In one episode, Lisa is trying to protect the oldest tree in Springfield. Creator Matt Groening has stated that Springfield has much in common with Portland, Oregon, the city he grew up in (see Matt Groening's Portland), and the name "Springfield" was chosen because virtually every state has a town or city with that name. One of the couch gags zoomed out and showed the Simpson's house in Springfield, Illinois. As the camera pans away from earth, the concentric radio signals are shown to be emanating from Louisiana. When Kang initiates telepathic contact with Maggie, baby Maggie responds by transmitting a signal with her pacifier. During one of the Halloween specials, it is proposed that Kang, a space alien, is the real father of Maggie. There is also evidence that the Simpsons live in Louisiana. The star is placed geographically in Kentucky. Also, in the episode, Brake My Wife, Please, when Homer breaks out in a singing routine, we can see a star on the map on which Homer walks from to California. Also, in the behind-the-scenes episode "Behind the Laughter", the narrator says "...but that wasn't the end for this Northern Kentucky family." Looking closely at a map of Kentucky in the northern part of the state, the towns of Simpsonville and its neighbor city Shelbyville can be clearly seen. In an earlier episode it was also implied that the family came from Kentucky. Burns states they will smuggle sugar in from south of the border to which Homer replies, "Oh, you mean Tennessee?", implying they live in Kentucky. In an episode during season 13, Mr. This Confederate symbol is an outrage, particularly because we are a northern state", meaning that the state could not be part of the old Confederacy. The Third Grade", the Capitol City Goofball mascot and delegate says "It is time to address our state's flag. Lisa vs. Also, in the episode "Bart vs. Another factor to consider is the weather, as a town in Florida would not have the large amounts of snow we see in the show during the Christmas episodes. There is also evidence to disprove this point in the episode "Kill the Alligator and Run", in which the family vacations to Florida (which Homer refers to as "USA's wang") and is prohibited from returning. 636 is in Missouri (See Where Is The Simpsons' Springfield? for more information on this issue.) According to the video game The Simpsons Hit & Run, the town of Springfield is in Florida, but this could be ruled out in the episode "Special Edna", in which a sign in Springfield shows the distance to Orlando too far for Springfield to be in the same state. Simpson's area code changes from 636 to 939. It seems it is kept indeterminate on purpose so that the location can suit any plot, as Springfield and its surrounding areas have been shown to contain coastlines, deserts, vast farmland, and tall mountains, or whatever the story requires. has been both suggested and ruled out by conflicting "evidence" of a location for Springfield, so that the town could not really be anywhere. Both the town itself and its location are fictional; nearly every state and region in the U.S. Throughout the show's history fans have tried to determine where Springfield is by taking the town's characteristics, surrounding geography and nearby landmarks as clues (as Lisa once said of the state, "It's a bit of a mystery, yes, but if you look at the clues, you'll figure it out"). The Simpsons is set in the fictional United States town of Springfield. Some of these, like Itchy and Scratchy, ultraviolent versions of Tom and Jerry, are fictional even within the Simpsons universe. For a comprehensive list, see characters from The Simpsons. Many of these characters have developed a vast cult following of their own, and many of them each serve to represent facets of the USA society that the show scathingly critiques. The show also has a vast array of quirky supporting characters, including co-workers, teachers, family friends, extended relatives, and local celebrities. There are other clues as well, such as the avocado-green kitchen equipment (this color was popular in the 1960s and '70s) and the family's two cars, both of which appear to have been manufactured in the early 1980s (Homer's being made from "recycled Soviet tanks"). The Simpsons go several years into the internet age before acquiring a computer, reflecting the fact that the Simpson family is perpetually several years out of date. The Simpson lifestyle yo-yos depending on whether or not Homer is employed at the time; Marge is largely a stay-at-home mom. The Simpson family (which sometimes includes Homer's father, Abraham "Abe" Simpson) lives in a relatively large four-bedroom house bordering a friendly neighbor on one side, Ned Flanders, and many varying things, including a cemetery, on the other. Homer describes his family as "upper lower middle class", and this appears to be about right. Some characters' ages have fluctuated throughout the years; this is most likely due to simple oversight on the part of the writers. Maggie is an eternal baby, and despite the fact that numerous years (and birthdays) clearly pass (for example, many Christmas episodes), the Simpsons do not appear to age. Lisa, the 8 year old once portrayed having a genius intellect (with adult mannerisms, perception and extraordinary articulation), has leveled into a more average girl yet brainy student, who also happens to be a vegetarian, Buddhist and jazz music fan who dreams of a better future (she is referred to as "the future of the family"). Bart, the oldest sibling at the age of 10, is a troublemaker and classroom terror ("the devil's cabana boy", as Lisa once described him) who thinks of himself as a rebel. Marge (of French origin) was once intelligent and sophisticated, but has come to conform with the stereotype of housewife/mother. Homer, a safety inspector at the Springfield Nuclear Power Plant, is a generally well-meaning buffoon whose short attention span often draws him into outrageous schemes and adventures. Bart, however, is an anagram for brat, with Groening having stated that he thought naming the boy "Matt" would be too obvious. The main characters were originally created by Matt Groening as part of a series of original animated segments for The Tracey Ullman Show. Over the course of the series Groening has used many of the themes present in his long-running comic strip series, Life in Hell. (For instance, the idea of creative school children constantly being persecuted and suppressed by totalitarian grown-ups stems from the strip.) Many of the characters in The Simpsons take their names from important people and places in Groening's life — for example Lisa, Maggie, Marge and Homer share names with Groening's sisters, mother and father respectively. . It is considered a sign of definite status as a celebrity or other important figure to be featured or asked to parody oneself in an episode of the show; this has become a phenomenon with many A-list celebrities willing to participate in even the most minute cameo appearance. The Simpsons was also one of the pioneering shows that changed the view of cartoons to a more adult standard. It has had a huge influence on post–Cold War popular culture. Highly satirical, the show lampoons many aspects of the human condition, but primarily parodies the "Middle American" lifestyle epitomized by its titular family, as well as American culture, society, and even television itself. The Simpsons has been seen by many critics as one of the finest television shows ever; it was named the best television series of the 20th century by TIME magazine in 1998, and it made the top 10 on TV Guide's list of the greatest shows of all time in 2002. It is produced by Gracie Films for 20th Century Fox. The TV series, created by Matt Groening, is a spinoff of a series of animated shorts originally aired on The Tracey Ullman Show. The Simpsons is the longest-running USA animated television series and overall sitcom, with 17 seasons and 367 episodes since it debuted on December 17, 1989 on FOX. Often, when a person escapes or just leaves a room, the sound of a pulling out car will be audible immediately, no matter how long the realistic way from the door/exit to the car would be. Maggie never speaks. Burns, which leads to the occasional awkward situation. Burns's assistant, is secretly in love with Mr. Smithers, Mr. Homer, when frustrated or making a obvious blunder, shouts out the famous catch phrase 'D'OH!'. Maggie Simpson falls when she tries to walk and is constantly sucking on a pacifier. When Marge doesn't approve of something she'll make a throaty humming noise similar to hmmmm. Homer always choking Bart. Nelson Muntz appears from time to time to mock a funny situation with his own 'HA-ha!'. The famous 'Aye carumba!', 'Don't have a cow, man!', and 'Eat my shorts!' lines were used extensively by Bart in the earlier seasons. This gag seems to have been retired. One example would be the Missing Baby Hotline playing "Baby come back" by Player. The "Stay-On-the-Line and Cry" routine (more prevalent in earlier seasons of the show), a running gag in which one of the members of the Simpson family - usually Homer and Marge - would wait on the phone, but then break down and cry when a popular song pertaining to the situation would be played as Soft/Easy Listening Music. Krusty the Clown never remembers Bart despite the numerous times Bart helped him out of jams. The "Family Guy" gag, a recent gag in which the creators of the Simpsons will poke fun at Family Guy from time to time. Barney Gumbel's trademark belch (this was first introduced in Season 1, but then modified for all subsequent seasons). (unintelligible)". blaargh.. (tasty thing).. Homer encounters something tasty, like a donut, and utters in a long drawn-out tone: "Mmmm.. Smithers has to remind him.). Burns unable to remember Homer Simpsons' name, despite the countless times the two have worked together (and every time Mr. Mr. This is usually followed by Moe shouting threats back at Bart through the phone. Bart's Prank Call, a recurring gag in which Bart Simpson would make a call to the oblivious Moe of Moe's Tavern and would get him to fall for the trap every time. How to draw the Simpsons by Matt Groening *Miniclip.com. Keller. The Gospel According to Bart: Examining the Religious Elements of The Simpsons by Beth L. Conard (Editor), Aeon Skoble (Editor) ISBN 0812694333. The Simpsons and Philosophy: The D'oh! of Homer by William Irwin (Editor), Mark T. Parvin ISBN 066422590X. Pinsky, Samuel F. The Gospel According to the Simpsons: Leaders Guide for Group Study by Mark I. Pinsky ISBN 0664224199. The Gospel According to The Simpsons: The Spiritual Life of the World's Most Animated Family by Mark I. The Simpsons And Society: An Analysis Of Our Favorite Family And Its Influence In Contemporary Society by Steven Keslowitz ISBN 1587362538. Leaving Springfield: The Simpsons and the Possibility of Oppositional Culture (Contemporary Film and Television Series) by John Alberti ISBN 0814328490. Planet Simpson: How a Cartoon Masterpiece Documented an Era and Defined a Generation by Chris Turner ISBN 0679313184. Produced "The Fat and the Furriest" and "She Used to Be My Girl". Produced "The Simpsons 138th Episode Spectacular". Jointly produced "Radioactive Man" with Anivision. Produced animation for episodes from season four onwards. Produced animation for episodes from seasons 3–10. Produced various episodes throughout the run of the series. Exclusively produced the first two seasons of the series. The family attempts to sit on the couch as something goes awry in an often surreal manner. Homer screams in a different way (only done in the first couple of seasons);. Bart weaves between pedestrians but in the first season, he is seen passing a queue of people waiting for a bus;. Lisa may play a different solo on her baritone saxophone;. Bart writes something different on the chalkboard;. A fantasy in which one of the Simpsons imagines how something might turn out. Burns, is doing at the time. Scenes that cut from the main action to show what a secondary character, like Krusty or Mr. TV anchorman Kent Brockman reporting on the events of the plot. Many recurring minor characters appear and speak. A crowd scene, in which the entire town of Springfield convenes to witness some notable event, protest something, attend a civic meeting, or even start a riot. A scene in which one or more Simpsons are watching a TV program, which the viewer watches along with them, or watches them watch it, often to be interrupted. A scene in which Homer is at Moe's Tavern escaping the hassles of work and family to be with his friends. This is often near the start of the episode. A scene in the morning in which Marge is preparing breakfast, and the kids and Homer are eating before going to work or school as they talk about what they are going to do. Conceptually this is very similar to the "Homer and Marge in bed" scenes, but including the children. A scene in which the family is eating dinner together and talking about the events of the plot. A scene, often near the middle of the show, in which Homer and Marge are in bed together discussing the events of the story so far. A scene in which Bart prank calls Moe. After a few minutes there, the main plot begins. A scene at the very beginning of the show in which the family goes somewhere together, like a cartoon festival or a cider mill. The episode is a clip show. Sideshow Bob attempts to kill Bart. Grampa Simpson needs help sorting out issues from his past and calls upon the main Simpsons family. (Because of these vacations the entire family has been to every continent on Earth with the exception of Antarctica.). The entire family goes on vacation. Lisa embraces or advocates the merits of a particular political cause or group. Bart causes a large problem and attempts to fix it. Homer and Marge break up, then get back together. Marge attempts to escape the monotony of keeping house by finding employment or taking up a hobby. Homer gets a new job (Simpson writers had Homer count 30 of them in a recent episode but the actual list is far longer) or attempts to make money in a get-rich-quick scheme. Evil and cruel, Burns is aided in his campaign of terror against the residents of Springfield by his trusted assistant Waylon Smithers, who secretly harbors an unrequited love for Burns. Montgomery Burns, owner of the Springfield Nuclear Plant and Homer Simpson's boss. While most of these characters are more incompetent than truly evil there is one true sadist: C. Reverend Timothy Lovejoy, the pastor of the local church, is judgmental and moralistic (but only regarding other people), with a monotone voice that always puts Homer to sleep during Sunday sermons. Based on comedian Rich Hall. Moe Szyslak, the owner of Moe's Tavern (where Homer spends most of his free time), is a borderline sociopath who threatens people with his loaded shotgun, and attempts suicide every Christmas. Her name is an allusion to the word Crabapple, as if to suggest the USA idiom. Edna Krabappel is Bart's depressed, sexually-promiscuous, chain-smoking elementary school teacher who is impatient and ignorant of her class, and demands darkness and silence when she is hung over. Ms. He has frequent flashbacks to his capture and imprisonment by the Viet Cong, and in early seasons, Skinner was repeatedly likened to Norman Bates in Psycho though this ultimately was dropped later on in the series. Seymour Skinner - who sounds like Charles Kuralt - the principal of Springfield Elementary School, is an uptight, humorless bachelor who lives with his domineering mother. Kennedy — is a corrupt, spendthrift womanizer. Mayor Quimby — who sounds like John F. Robinson-influenced tone) is very obese, stupid, lazy, corrupt and not overly concerned with constitutional rights (not to mention that he somewhat resembles a pig). Springfield police chief Clancy Wiggum (voiced by Hank Azaria in an Edward G. Marge Simpson is also of the 1950s stereotype category, and attempts to exercise control to compensate for her husband's failings. Homer is thoughtless and irresponsible, the antithesis of the ideal 1950s TV father, though he always comes through for his family in the end. |