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Gregory Goodwin Pincus

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Gregory Goodwin Pincus (April 9, 1903 - August 22, 1967), American physician, biologist, and researcher, was co-inventor of the contraceptive pill. Pincus began studying hormonal biology and steroidal hormones early in his career. He was instrumental in persuading Searle to fund this research, at a time when Pfizer and Parke-Davis were reluctant to fund human trials.

Pincus's first breakthrough came early, when he was able to produce in vitro fertilization in rabbits in 1934.

His experiments involving parthenogenesis produced a rabbit that appeared on the cover of Look magazine in 1937 and led to his dismissal from Harvard University.

In 1953, Margaret Sanger and Katherine McCormick sought out Pincus for a project involving contraception. Pincus, along with Min-Chueh Chang, investigated and established that progesterone would act as an inhibitor to ovulation. However, despite early success in preventing ovulation, and therefore fertilization, a study with beagle dogs that had been on the pill for three years showed an incidence of breast tissue nodules. Pincus had to establish long term safety, as well as efficacy, of his progesterone contraceptive.

In order to prove the safety of "the pill," human trials had to be conducted. These were initiated on medical students and institutionalized patients in Massachusetts. There was a high incidence of side effects, which led to the Massachusetts trials being abandoned when the women refused to continue taking the contraceptive. Puerto Rico was selected as a trial site in 1954, in part because there was an existing network of 67 birth control clinics servicing low-income women on the island. Trails began there in 1956 and were supervised by Dr. Edris Rice-Wray. Women, once again, experienced severe side effects from "the pill" (Envoid). Rice-Wray wrote Pincus and reported that Envoid "gives one hundred percent protection against pregnancy" but causes "too many side reactions to be acceptable". Pincus disagreed. The trails went on and were expanded to Haiti, despite high attrition rates, due to the large number of women eager to try this form of contraception. In May 1960, the FDA approved Envoid for contraceptive use.

Pincus's successes led to Searle introducing the first widely available oral contraceptive ("the pill"). The social, religious, ethical, and medical ramifications of this discovery are still being felt throughout the world, and his discoveries also led to the burgeoning sciences of steroidal hormone research, sex hormone research, and new forms of oncology. Pincus's work may be some of the most influential science of the twentieth century.

See also: A&E's Biography of the Millennium

References

  • Briggs, Laura (2002). Reproducing Empire: Race, Sex, Science, and U.S. Imperialism in Puerto Rico. Los Angeles: University of California Press. ISBN 0520232585.
  • Tone, Andrea (2001). Devices and Desires. New York: Hill and Wang, A Division of Farrar, Strauss and Giroux. ISBN 080903817X.

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See also: A&E's Biography of the Millennium.
. Pincus's work may be some of the most influential science of the twentieth century. A four-time All-Star, Rolen is a .286 career hitter with 226 home runs and 831 RBI in 1195 games. The social, religious, ethical, and medical ramifications of this discovery are still being felt throughout the world, and his discoveries also led to the burgeoning sciences of steroidal hormone research, sex hormone research, and new forms of oncology. In a eight-year career, Rolen has won six Gold Glove Awards. Pincus's successes led to Searle introducing the first widely available oral contraceptive ("the pill"). Despite being injured for the last stretch of the season, he finished the year with a career-high .314 batting average, 34 home runs, and 124 RBI.

In May 1960, the FDA approved Envoid for contraceptive use. For much of the season, he led the National League in RBI, often ranked among the league leaders in most offensive statistics, and had the highest vote total of any player for the All-Star Game. The trails went on and were expanded to Haiti, despite high attrition rates, due to the large number of women eager to try this form of contraception. Rolen's 2004 season was arguably his best. Pincus disagreed. Later that year, he received an eight-year contract extension. Rice-Wray wrote Pincus and reported that Envoid "gives one hundred percent protection against pregnancy" but causes "too many side reactions to be acceptable". On July 29 2002, Rolen was traded, along with Doug Nickle, to the Cardinals for Plácido Polanco, Mike Timlin, and Bud Smith.

Women, once again, experienced severe side effects from "the pill" (Envoid). In that season, he was named National League Rookie of the Year. Edris Rice-Wray. Although drafted by the Philadelphia Phillies in the 2nd round of the 1993 amateur draft, he didn't receive playing time until 1997. Trails began there in 1956 and were supervised by Dr. Rolen grew up in Jasper, Indiana. Puerto Rico was selected as a trial site in 1954, in part because there was an existing network of 67 birth control clinics servicing low-income women on the island. Louis Cardinals.

There was a high incidence of side effects, which led to the Massachusetts trials being abandoned when the women refused to continue taking the contraceptive. Scott Bruce Rolen (born April 4, 1975 in Evansville, Indiana) is an American baseball player, who currently plays at third base for the St. These were initiated on medical students and institutionalized patients in Massachusetts.
. In order to prove the safety of "the pill," human trials had to be conducted. Pincus had to establish long term safety, as well as efficacy, of his progesterone contraceptive.

However, despite early success in preventing ovulation, and therefore fertilization, a study with beagle dogs that had been on the pill for three years showed an incidence of breast tissue nodules. Pincus, along with Min-Chueh Chang, investigated and established that progesterone would act as an inhibitor to ovulation. In 1953, Margaret Sanger and Katherine McCormick sought out Pincus for a project involving contraception. His experiments involving parthenogenesis produced a rabbit that appeared on the cover of Look magazine in 1937 and led to his dismissal from Harvard University.

Pincus's first breakthrough came early, when he was able to produce in vitro fertilization in rabbits in 1934. He was instrumental in persuading Searle to fund this research, at a time when Pfizer and Parke-Davis were reluctant to fund human trials. Pincus began studying hormonal biology and steroidal hormones early in his career. Gregory Goodwin Pincus (April 9, 1903 - August 22, 1967), American physician, biologist, and researcher, was co-inventor of the contraceptive pill.

ISBN 080903817X. New York: Hill and Wang, A Division of Farrar, Strauss and Giroux. Devices and Desires. Tone, Andrea (2001).

ISBN 0520232585. Los Angeles: University of California Press. Imperialism in Puerto Rico. Reproducing Empire: Race, Sex, Science, and U.S.

Briggs, Laura (2002).